Evidence map›Paper›PMID 42168793›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Age-related behavioral and molecular landmarks in new mouse models for studying Alzheimer's disease in Down syndrome.

Monika Rataj Baniowska, Paige Mumford, Francesca Prestia, Pauline Stephan, Millie Beament, Marie-Christine Birling, Chiara Lanzillotta, Letizia Ciafardini, Eugenio Barone, Gloria Lau and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Monika Rataj BaniowskaInstitut de Génétique Biologie Moléculaire et Cellulaire, IGBMC, UMR 7104- UMR-S 1258, Université de Strasbourg, CNRS, Inserm, Illkirch, France.
Paige MumfordUK Dementia Research Institute at UCL, London, UK.
Francesca PrestiaDepartment of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, Rome, Italy.
Pauline StephanInstitut de Génétique Biologie Moléculaire et Cellulaire, IGBMC, UMR 7104- UMR-S 1258, Université de Strasbourg, CNRS, Inserm, Illkirch, France.
Millie BeamentUK Dementia Research Institute at UCL, London, UK.
Marie-Christine BirlingUniversité de Strasbourg, CNRS, Inserm, PHEN-Institut Clinique de la Souris, PHEN-ICS, CELPHEDIA, UAR2062, US66, Illkirch, France.
Chiara LanzillottaDepartment of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, Rome, Italy.
Letizia CiafardiniDepartment of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, Rome, Italy.
Eugenio BaroneDepartment of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, Rome, Italy.
Gloria LauUK Dementia Research Institute at UCL, London, UK.
Claire ChevalierInstitut de Génétique Biologie Moléculaire et Cellulaire, IGBMC, UMR 7104- UMR-S 1258, Université de Strasbourg, CNRS, Inserm, Illkirch, France.
Chadia NahyInstitut de Génétique Biologie Moléculaire et Cellulaire, IGBMC, UMR 7104- UMR-S 1258, Université de Strasbourg, CNRS, Inserm, Illkirch, France.
Nadia MessaddeqInstitut de Génétique Biologie Moléculaire et Cellulaire, IGBMC, UMR 7104- UMR-S 1258, Université de Strasbourg, CNRS, Inserm, Illkirch, France.
Thais LestraUK Dementia Research Institute at UCL, London, UK.
Yixing WuUK Dementia Research Institute at UCL, London, UK.
Valérie NalessoInstitut de Génétique Biologie Moléculaire et Cellulaire, IGBMC, UMR 7104- UMR-S 1258, Université de Strasbourg, CNRS, Inserm, Illkirch, France.
Fabio Di DomenicoDepartment of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, Rome, Italy.
Frances WisemanUK Dementia Research Institute at UCL, London, UK.
Yann HeraultInstitut de Génétique Biologie Moléculaire et Cellulaire, IGBMC, UMR 7104- UMR-S 1258, Université de Strasbourg, CNRS, Inserm, Illkirch, France.ORCID https://orcid.org/0000-0001-7049-6900

Funding

Agence Nationale de la Recherche ANR-10-IDEX-0002Agence Nationale de la Recherche ANR-10-IDEX-0002-02Agence Nationale de la Recherche ANR-17-EURE-0023Agence Nationale de la Recherche ANR-20-SFRI-0012Alzheimer's Research UK ARUK-SRF2018A-001European Commission 848077Fondation Jérôme Lejeune 2083Istituto Pasteur-Fondazione Cenci Bolognetti 45U-4.ITSapienza Università di Roma RG1181642744DF59UK Dementia Research Institute UKDRI-1014
6 · The paper itself

Abstract

introductionDown syndrome (DS) is the leading genetic cause of intellectual disability and Alzheimer's disease (AD), with over 90% of individuals developing AD-related dementia (DSAD). The triplication of the APP gene on chromosome 21 drives early amyloid-β (Aβ) accumulation, but other Hsa21 genes also contribute to pathology. Current DSAD models are limited by species-specific Aβ differences.

methodsWe developed and characterized two novel DSAD mouse models with partial humanization of Aβ.

resultsThese models exhibit early AD features: cognitive deficits, hyperactivity, altered novelty and risk responses, tau hyperphosphorylation, and endolysosomal dysfunction. Amyloid precursor protein (APP) processing shifts toward β-secretase, increasing CTF-β and altering Aβ dynamics. Aβ humanization modulates behavior, improving specific cognitive tasks but enhancing anxiety traits. Myelinosome formation and impaired autophagic flux further align these models with human AD pathology. DISCUSSION: They offer valuable tools to investigate early DSAD mechanisms and therapeutic strategies, pending development of a fully humanized trisomic model.

Indexed as

AgingAlzheimer DiseaseBehavior, AnimalDisease Models, AnimalDown SyndromeAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsBrainHumansMaleMiceMice, Transgenictau ProteinsAmyloid beta-PeptidesAmyloid beta-Protein Precursortau Proteinsageinganxietybrain metabolismcognitionDown syndromelearning and memorymouse modelneurodegeneration

Identifiers

PMID42168793
PMCPMC13240120

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.