ArticleInternational journal of molecular medicine2026
Ginsenoside Rg3 potentiates cisplatin antitumor activity while mitigating nephrotoxicity through SIRT1‑mediated suppression of the NLRP3 inflammasome.
Article in International journal of molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Lung cancer is one of the most common causes of cancer‑related mortality worldwide, with cisplatin (CP) being a key chemotherapeutic agent. However, its use is limited by nephrotoxicity and drug resistance. Ginsenoside Rg3 (Rg3) has anticancer properties and potential protective effects on normal tissues. The present study investigated the therapeutic effect of Rg3 and CP in suppressing the proliferation of lung carcinoma cells (LLCs) and inhibiting tumor growth, using both
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