Evidence map›Paper›PMID 42169673›Full record

ReviewJournal of enzyme inhibition and medicinal chemistry2026

Mechanisms of traditional Chinese medicine in enhancing the efficacy and reducing the toxicity of immune checkpoint inhibitors

Junying Pan, Liying Yang, Haoyu Wang, Yinghua Chen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of enzyme inhibition and medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Junying PanDepartment of Tuina, First Affiliated Hospital Heilongjiang University of Chinese Medicine, Harbin, China.
Liying YangDeparment of Geriatrics, The First Psychiatric Hospital in Harbin, Harbin, China.
Haoyu WangDepartment of Acupuncture, First Affiliated Hospital Heilongjiang University of Chinese Medicine, Harbin, China.
Yinghua ChenDepartment of Acupuncture, First Affiliated Hospital Heilongjiang University of Chinese Medicine, Harbin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune checkpoint inhibitors (ICIs) face challenges of drug resistance and immune-related adverse events (irAEs). Traditional Chinese medicine (TCM)-including single herbs, compounds, and active monomers-enhances ICI efficacy and reduces toxicity by remodeling the tumor immune microenvironment, regulating gut microbiota, and modulating key immune pathways. TCM also alleviates ICI-induced colitis and myocarditis, demonstrating the value of holistic and syndrome-differentiated therapy. Future research should clarify synergistic mechanisms to advance precise integration of TCM and ICI immunotherapy.

Indexed as

Drugs, Chinese HerbalGastrointestinal MicrobiomeImmune Checkpoint InhibitorsMedicine, Chinese TraditionalNeoplasmsTumor MicroenvironmentAnimalsHumansDrugs, Chinese HerbalImmune Checkpoint Inhibitorsgut microbiotaimmune checkpoint inhibitors (ICIs)integrated Chinese-Western medicineTraditional Chinese Medicinetumor microenvironment

Identifiers

PMID42169673
PMCPMC13202700

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.