Evidence map›Paper›PMID 42170252›Full record

ArticleTranslational lung cancer research2026

Novel lipid metabolism-related gene signature associated with clinical and immune features in lung adenocarcinoma patients experiencing lymph node metastasis.

Shen Lao, Zisheng Chen, Yuan Zhang, Jianfu Li, Hengrui Liang, Yongmei Zheng, Xiaoyan Liu, Wei Wang, Wenhua Liang

Abstract read
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Article in Translational lung cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Shen Lao *Department of Thoracic Surgery and Oncology, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Healthy, Guangzhou, China.
Zisheng Chen *Department of Thoracic Surgery and Oncology, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Healthy, Guangzhou, China.
Yuan Zhang *Department of Thoracic Surgery and Oncology, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Healthy, Guangzhou, China.
Jianfu Li *Department of Thoracic Surgery and Oncology, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Healthy, Guangzhou, China.
Hengrui LiangDepartment of Thoracic Surgery and Oncology, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Healthy, Guangzhou, China.
Yongmei ZhengDepartment of Thoracic Surgery and Oncology, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Healthy, Guangzhou, China.
Xiaoyan LiuDepartment of Thoracic Surgery and Oncology, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Healthy, Guangzhou, China.
Wei WangDepartment of Thoracic Surgery and Oncology, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Healthy, Guangzhou, China.
Wenhua LiangDepartment of Thoracic Surgery and Oncology, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Healthy, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Research has increasingly shown that lipid metabolism contributes to lymph node metastasis (LNM) and the progression of cancer. This study investigates the role of lipid metabolism in LNM of lung adenocarcinoma (LUAD). Methods: We gathered clinicopathological data and RNA-sequencing information from LUAD patients using The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. We identified differentially expressed lipid metabolism-related genes (LMRGs) in LUAD with and without LNM. Using a prognostic risk scoring system, we correlated LMRGs with clinicopathological outcomes, genomic alterations, immune features, immunotherapy responses, and drug susceptibility. Results: A three-gene lipid metabolic signature ( Conclusions: Our findings provide new insights into the molecular mechanisms underlying regional metastasis in LUAD related to lipid metabolism and highlight the potential for precision therapies targeting this pathway.

Indexed as

immune infiltrationLipid metabolismlung adenocarcinoma (LUAD)lymph node metastasis (LNM)metabolic reprogramming

Identifiers

PMID42170252
PMCPMC13186678

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.