ArticleAmerican journal of physiology. Heart and circulatory physiology2026
Bioactive factors in endometriosis peritoneal fluid remodel human cardiomyocytes.
Article in American journal of physiology. Heart and circulatory physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Endometriosis is associated with increased cardiovascular disease (CVD) risk, yet the cellular basis for this relationship remains unclear. We examined whether peritoneal fluid (PF) from women with endometriosis alters cardiomyocyte behavior in vitro. Human-induced pluripotent stem cell-derived cardiomyocytes were exposed for 48 h to standard or hypertrophic media supplemented with peritoneal fluid from endometriosis or control patients. Beating frequency was measured using calcium transient imaging, differential gene expression was assessed with the Human CVD-PCR array, and sarcomere features were quantified using gray-level cooccurrence matrix (GLCM)-based texture analysis. Under standard conditions, PF increased beats per minute compared with media alone (control
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