ArticleNature communications2026
Long-term temporal stability of circulating proteins in older adults.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Genetic drivers of protein changes over time: Findings, considerations, and approaches in TOPMed cohorts and UK Biobank.bioRxiv : the preprint server for biology · 2026Article
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16 authors.
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Abstract
Circulating proteins provide insights into an individual's health and aging trajectory. However, little is known about their long-term temporal stability. We evaluated the five-year temporal stability of 7288 serum proteins in 3093 participants (mean age 75 years) of the AGES-Reykjavik study. We observe wide variability in protein temporal stability, independent of transcriptomic stability in tissues. Temporally stable proteins tend to be extracellular, secreted, and tissue-specific, while temporally variable proteins are typically involved in intracellular housekeeping functions. Generally, protein levels become more stable with age, and for some proteins, temporal stability differs by sex. Similar patterns and consistent temporal stability were observed for a subset of plasma proteins in the Cardiovascular Health Study. Genetic factors and disease state have widespread effects on the temporal stability of the proteome, while the co-regulatory structure of the proteome is largely retained over time. Our findings underscore the protein-specific differences in long-term temporal stability, which are particularly important to consider in the context of biomarker development and precision medicine.
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