Evidence map›Paper›PMID 42173841›Full record

ArticleCell death & disease2026

Carvedilol triggers ferroptosis in hepatic stellate cells via the ATF4/SAT1 axis promoting spermidine depletion to ameliorate liver fibrosis.

Yifu Xia, Sining Wang, Junyuan Zhu, Yuwen Chen, Xu Liu, Chunqing Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yifu Xia *Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Sining Wang *Department of Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Junyuan ZhuDepartment of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Yuwen ChenDepartment of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Xu LiuDepartment of Infectious Diseases and Hepatology, The Second Hospital of Shandong University, Jinan, China.
Chunqing ZhangDepartment of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. zhangchunqing_sdu@163.com.ORCID http://orcid.org/0000-0001-8711-1579

Funding

Natural Science Foundation of Shandong Province (Shandong Provincial Natural Science Foundation) ZR2022ZD21
6 · The paper itself

Abstract

Liver fibrosis is a major pathological consequence of chronic liver injury, and carvedilol, a drug effective in reducing portal hypertension, has been shown to exert anti-fibrotic effects in recent studies, yet the precise molecular mechanism underlying this activity remains elusive. This study aimed to investigate the core scientific question of whether carvedilol alleviates liver fibrosis by inducing ferroptosis in hepatic stellate cells (HSCs) and to clarify the corresponding regulatory mechanisms. Using a CCl

Indexed as

Activating Transcription Factor 4CarvedilolFerroptosisHepatic Stellate CellsLiver CirrhosisSpermidineAnimalsCarbon TetrachlorideCell LineHumansMaleMiceMice, Inbred C57BLSignal TransductionActivating Transcription Factor 4Carbon TetrachlorideCarvedilolSpermidine

Identifiers

PMID42173841
PMCPMC13369927

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.