Evidence map›Paper›PMID 42173913›Full record

ArticleNature communications2026

Iron overload in the tumor microenvironment induces CD8

Zhenyu Lin, Huanpeng Chen, Yujing Ke, Hanyue Xiao, Chao Li, Zilong Wu, Huixin Gao, Nanqi Huang, Lijuan Lu, Peng Sun and 1 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Berberine from Tibetan MedicineCancer management and research · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhenyu LinGuangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou, China.
Huanpeng ChenGuangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou, China.ORCID http://orcid.org/0000-0002-8810-0393
Yujing KeGuangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou, China.ORCID http://orcid.org/0009-0002-0980-6521
Hanyue XiaoGuangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou, China.
Chao LiGuangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou, China.ORCID http://orcid.org/0009-0009-0780-5876
Zilong WuGuangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou, China.
Huixin GaoDepartment of Clinical Laboratory, Guangzhou Women and Children Medical Center, Guangzhou Medical University, Guangzhou, China.
Nanqi HuangDepartment of Gastrointestinal Surgery, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Lijuan LuDepartment of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Peng SunState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.ORCID http://orcid.org/0000-0002-6589-6827
Yingjie BianGuangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou, China. bian_yingjie@gzlab.ac.cn.ORCID http://orcid.org/0000-0002-9599-9907

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32370971
6 · The paper itself

Abstract

While iron homeostasis in cancer cells is well-established, its role in mediating crosstalk between tumors and CD8

Indexed as

CD8-Positive T-LymphocytesFerroptosisIron OverloadNeoplasmsTumor MicroenvironmentAnimalsCation Transport ProteinsCell Line, TumorFemaleHepcidinsHumansIronMiceMice, Inbred C57BLReceptors, Chimeric AntigenCation Transport ProteinsHepcidinsIronReceptors, Chimeric Antigen

Identifiers

PMID42173913
PMCPMC13385831

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.