Evidence map›Paper›PMID 42174184›Full record

ArticleNature metabolism2026

Semaglutide drives weight loss through cAMP-dependent mechanisms in GLP1R-expressing hindbrain neurons.

Claire Gao, Isabelle C Geneve, Shakira Rodriguez-Gonzalez, Chia Li, Kaitlyn McElhern, Marc L Reitman, Andrew Lutas, Michael J Krashes

Abstract read
PubMed Publisher
In one paragraph

Article in Nature metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Functional segregation of body-brain signals in the area postrema.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Claire GaoDiabetes, Endocrinology, & Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-8832-5103
Isabelle C GeneveDiabetes, Endocrinology, & Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
Shakira Rodriguez-GonzalezDiabetes, Endocrinology, & Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
Chia LiDiabetes, Endocrinology, & Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
Kaitlyn McElhernDiabetes, Endocrinology, & Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
Marc L ReitmanDiabetes, Endocrinology, & Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-0426-9475
Andrew Lutas *Diabetes, Endocrinology, & Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA. andrew.lutas@nih.gov.ORCID http://orcid.org/0000-0002-6991-2898
Michael J Krashes *Diabetes, Endocrinology, & Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA. michael.krashes@nih.gov.ORCID http://orcid.org/0000-0003-0966-3401

Funding

U.S. Department of Health & Human Services | National Institutes of Health (NIH) 1ZIADK075087-07U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) 1ZIA-DK075169-2U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) Fi2-GM154675
6 · The paper itself

Abstract

Glucagon-like peptide 1 receptor (GLP1R) agonists, such as semaglutide, drive weight loss by binding to GLP1Rs-classically described as G

Indexed as

Cyclic AMPGlucagon-Like Peptide-1 ReceptorGlucagon-Like PeptidesNeuronsRhombencephalonWeight LossAnimalsMaleMiceSemaglutideSignal TransductionCyclic AMPGlp1r protein, mouseGlucagon-Like Peptide-1 ReceptorGlucagon-Like PeptidesSemaglutide

Identifiers

PMID42174184

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.