ArticleAnalytical and bioanalytical chemistry2026
Development and validation of a multiplexed targeted HILIC-HRMS assay for quantitative analysis of hepatocellular carcinoma circulating biomarkers.
Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Sub-3 μm porous graphitic carbon for highly polar metabolomics: orthogonal selectivity and comparison with HILIC and reversed-phase chromatography.Analytical and bioanalytical chemistry · 2026Article
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11 authors.
Funding
Abstract
Early and accurate diagnosis of hepatocellular carcinoma (HCC) remains a major clinical challenge, particularly in patients with chronic hepatitis C virus (HCV) infection, where standard biomarkers such as alpha-fetoprotein (AFP) often lack sensitivity and specificity. Numerous biomarkers have emerged from untargeted metabolomics and lipidomics approaches; nevertheless, most of these studies provide only relative amounts and do not perform quantitative analysis as further validation. To address this challenge, we developed and validated a targeted method to quantitatively measure panels of biomarkers previously identified as predictive of HCC in untargeted analyses. A high-throughput (6 min) HILIC-HRMS method, based on a multiplexing-HRMS strategy, was developed and validated to measure a panel of lysophosphatidylcholines (LPCs) and carnitines (CARs) in plasma samples from 92 HCC patients. The method showed satisfactory performances in terms of sensitivity (LOD
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