Evidence map›Paper›PMID 42174231›Full record

ArticleMolecular psychiatry2026

Microbial Legacy: Mycobacterium vaccae ATCC 15483

Jessica Schiele, Pei-Ling Tsai, Tamara Schimmele, Sina Beck, Maren Meyer, Marco Mannes, Luke W Desmond, Reiner Noschka, Markus Huber-Lang, Melanie Haffner-Luntzer and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jessica Schiele *Laboratory for Molecular Psychosomatics, Department of Psychosomatic Medicine and Psychotherapy, Ulm University Medical Center, 89081, Ulm, Germany.
Pei-Ling Tsai *Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, 60528, Frankfurt, Germany.ORCID http://orcid.org/0000-0003-0233-703X
Tamara SchimmeleLaboratory for Molecular Psychosomatics, Department of Psychosomatic Medicine and Psychotherapy, Ulm University Medical Center, 89081, Ulm, Germany.
Sina BeckLaboratory for Molecular Psychosomatics, Department of Psychosomatic Medicine and Psychotherapy, Ulm University Medical Center, 89081, Ulm, Germany.ORCID http://orcid.org/0009-0003-6964-5819
Maren MeyerInstitute of Orthopaedic Research and Biomechanics, Ulm University Medical Center, 89081, Ulm, Germany.
Marco MannesInstitute of Clinical and Experimental Trauma-Immunology, Ulm University Medical Center, 89081, Ulm, Germany.
Luke W DesmondDepartment of Integrative Physiology, Department of Psychology and Neuroscience, Center for Neuroscience and Center for Microbial Exploration, University of Colorado Boulder, Boulder, CO, 80309, USA.
Reiner NoschkaInstitute of Medical Microbiology and Hygiene, Ulm University Medical Center, 89081, Ulm, Germany.
Markus Huber-LangInstitute of Clinical and Experimental Trauma-Immunology, Ulm University Medical Center, 89081, Ulm, Germany.
Melanie Haffner-LuntzerInstitute of Orthopaedic Research and Biomechanics, Ulm University Medical Center, 89081, Ulm, Germany.
Marc N JarczokDepartment of Psychosomatic Medicine and Psychotherapy, Ulm University Medical Center, 89081, Ulm, Germany.
Christopher A LowryDepartment of Integrative Physiology, Department of Psychology and Neuroscience, Center for Neuroscience and Center for Microbial Exploration, University of Colorado Boulder, Boulder, CO, 80309, USA.ORCID http://orcid.org/0000-0003-3920-5575
Andreas ReifGoethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, 60528, Frankfurt, Germany.ORCID http://orcid.org/0000-0002-0992-634X
Dominik LanggartnerLaboratory for Molecular Psychosomatics, Department of Psychosomatic Medicine and Psychotherapy, Ulm University Medical Center, 89081, Ulm, Germany.
Steffen StengerInstitute of Medical Microbiology and Hygiene, Ulm University Medical Center, 89081, Ulm, Germany.
David A Slattery *Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, 60528, Frankfurt, Germany.ORCID http://orcid.org/0000-0001-8753-5005
Stefan O Reber *Laboratory for Molecular Psychosomatics, Department of Psychosomatic Medicine and Psychotherapy, Ulm University Medical Center, 89081, Ulm, Germany. stefan.reber@uni-ulm.de.ORCID http://orcid.org/0000-0002-1583-7618

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) German Research 251293561Deutsche Forschungsgemeinschaft (German Research Foundation) RE 2911/ 23-1Deutsche Forschungsgemeinschaft (German Research Foundation) SL 141/ 6-1
6 · The paper itself

Abstract

According to the "Old Friends" hypothesis, the increased prevalence of stress-associated disorders in urban concrete landscapes of high-income countries is at least in part due to a reduced exposure to immunoregulatory microorganisms. The latter is particularly impactful when occurring during early prenatal and postnatal life. Accordingly, our own preclinical studies demonstrate that non-pathogenic rapid-growing mycobacteria, including Mycobacterium (M.) vaccae NCTC 11659 and M. vaccae ATCC 15483

Indexed as

MicrobiotaStress, PsychologicalAnimalsFecesFemaleMaleMiceMice, Inbred C57BLMycobacteriaceaeMycobacteriumStress, Physiological

Identifiers

PMID42174231
PMCPMC13569420

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.