SynthesisBMC medicine2026
Quantitative assessment of efficacy and evaluation of feasibility of exercise training protocols in adult and pediatric primary mitochondrial disease.
Synthesis in BMC medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
11 authors.
Funding
Abstract
backgroundExercise has been demonstrated to be effective in the general population and in a small number of Primary Mitochondrial Disease (PMD) human studies, raising the potential of exercise as standard of care in PMD. However, standardized exercise prescriptions have not been established in this heterogeneous patient population. This study aimed to identify effective and feasible exercise training protocols, to inform the design of rigorous exercise studies in adults and/or children with PMD. This was achieved through integration of a structured feasibility evaluation preceded by a quantitative review of published PMD studies, with specific focus on subgroup analyses by exercise type (aerobic, resistance, interval, and combination exercise).
methodsA systematic literature review was conducted to identify published exercise studies in PMD cohorts. Due to the limited number of PMD exercise studies, the search was expanded to include disorders with secondary mitochondrial dysfunction (SMD), with similar symptoms of muscle weakness, muscle fatigue and exercise intolerance, as occurs in PMD. In total, 77 studies comprising 109 exercise training protocols were identified. Of those, a quantitative analysis was performed on 37 PMD and SMD studies reporting key outcome measures to assess the effects of aerobic, resistance, combination or interval exercise training. All 109 exercise training protocols were then systematically evaluated for feasibility, as defined by the likelihood of successful implementation in future exercise studies of PMD, using a standardized scoring system.
resultsResults of our quantitative analysis demonstrate the significant effect of distinct exercise types including aerobic exercise training on relative peak oxygen consumption (VO
conclusionsResults of this study highlight specific exercise training protocols that merit assessment in future rigorously designed exercise studies to determine their feasibility and therapeutic efficacy in adults and/or children with PMD.
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42174583What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.