Evidence map›Paper›PMID 42176309›Full record

ArticleJournal of applied clinical medical physics2026

Optimization of CBCT-guided imaging schedules for left-sided postmastectomy radiotherapy using VMAT: A dosimetric, radiobiological, and cost analysis.

Denghong Liu, Changxu Lu, Xueyi Zou, Liping Liu, Lu Liu, Li Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied clinical medical physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Denghong LiuRadiotherapy Physics & Technology Center, Cancer Center, West China Hospital, Sichuan University, Chengdu, P.R. China.ORCID https://orcid.org/0009-0002-7720-4573
Changxu LuRadiotherapy Physics & Technology Center, Cancer Center, West China Hospital, Sichuan University, Chengdu, P.R. China.
Xueyi ZouRadiotherapy Physics & Technology Center, Cancer Center, West China Hospital, Sichuan University, Chengdu, P.R. China.
Liping LiuRadiotherapy Physics & Technology Center, Cancer Center, West China Hospital, Sichuan University, Chengdu, P.R. China.
Lu LiuRadiotherapy Physics & Technology Center, Cancer Center, West China Hospital, Sichuan University, Chengdu, P.R. China.
Li ZhouRadiotherapy Physics & Technology Center, Cancer Center, West China Hospital, Sichuan University, Chengdu, P.R. China.ORCID https://orcid.org/0000-0002-3398-3002

Funding

National Natural Science Foundation of China 11905150
6 · The paper itself

Abstract

purposeThis study aimed to determine an appropriate frequency of image-guided (IG) schedules for left-sided postmastectomy radiotherapy by comprehensively evaluating dosimetric, radiobiological, imaging dose, and imaging-related cost outcomes.

methodsA retrospective analysis of 20 patients treated with volumetric modulated arc therapy (VMAT) was conducted. Virtual CT images were generated by deforming the pCT to daily cone-beam computed tomography (CBCT) using deformable image registration. Accumulated dose, tumor control probability (TCP), normal tissue complication probability (NTCP), imaging dose, and imaging-related cost were compared among six IG schedules: no image-guided (NIG), weekly image-guided (WIG), twice-weekly image-guided (TIG), thrice-weekly image-guided (THRIG), initial 3 days then weekly image-guided (3D + WIG), and daily image-guided (DIG).

resultsIncreasing the frequency of IG schedules significantly improved planning target volume (PTV) dose coverage (D

conclusionWhile high frequency IG schedules improve target dose coverage, they are associated with increased imaging dose and imaging-related cost. Within the CBCT-guided VMAT workflow evaluated in this study, THRIG may provide a balanced trade-off between treatment precision, safety, and cost.

Indexed as

Cone-Beam Computed TomographyRadiotherapy DosageUnilateral Breast NeoplasmsAged, 80 and overBreast NeoplasmsCosts and Cost AnalysisFemaleHumansMastectomyMiddle AgedOrgans at RiskRadiotherapy, Image-GuidedRetrospective Studiesbreast cancercost analysisdosimetryimage‐guided schedulesimaging doseradiobiology

Identifiers

PMID42176309
PMCPMC13240581

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.