Evidence map›Paper›PMID 42177837›Full record

ReviewRedox biology2026

Nitration in cancer signaling.

Inge Claassen, Nirbachita Adrita, Kevin B Chandler, Stephen M Black, Blaine R Roberts, Alvaro G Estevez, Joseph S Beckman, Maria Clara Franco

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Redox biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Inge ClaassenCenter for Translational Science, Florida International University, Port St. Lucie, Florida, 34987, USA; Department of Cellular & Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, Port St. Lucie, Florida, 34987, USA.
Nirbachita AdritaCenter for Translational Science, Florida International University, Port St. Lucie, Florida, 34987, USA; Department of Cellular & Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, Port St. Lucie, Florida, 34987, USA.
Kevin B ChandlerDepartment of Cellular & Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, Port St. Lucie, Florida, 34987, USA.
Stephen M BlackCenter for Translational Science, Florida International University, Port St. Lucie, Florida, 34987, USA; Department of Cellular & Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, Port St. Lucie, Florida, 34987, USA.
Blaine R RobertsDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, 30322, USA; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Alvaro G EstevezCenter for Translational Science, Florida International University, Port St. Lucie, Florida, 34987, USA; Department of Cellular & Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, Port St. Lucie, Florida, 34987, USA.
Joseph S BeckmanDepartment of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, 97331, USA; Linus Pauling Institute, Oregon State University, Corvallis, OR, 97331, USA.
Maria Clara FrancoCenter for Translational Science, Florida International University, Port St. Lucie, Florida, 34987, USA; Department of Cellular & Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, Port St. Lucie, Florida, 34987, USA. Electronic address: marfranc@fiu.edu.

Funding

Redox Signaling in NeurofibromatosisR01NS102479 · NINDS · OREGON STATE UNIVERSITY · PI FRANCO, MARIA CLARA · 2019 to 2023
$1.7M
NINDS NIH HHS R01 NS102479
6 · The paper itself

Abstract

Oxidative stress arises from an imbalance between the production of reactive oxygen and nitrogen species (ROS and RNS, respectively) and the capacity of cellular antioxidant defenses to neutralize them. In cancer, this imbalance drives pathological remodeling of signaling networks that promote tumor initiation and progression. Among RNS, nitric oxide (·NO) and its highly reactive derivative peroxynitrite (ONOO

Indexed as

NeoplasmsSignal TransductionAnimalsHumansNitric OxideOxidation-ReductionOxidative StressPeroxynitrous AcidProtein Processing, Post-TranslationalReactive Nitrogen SpeciesReactive Oxygen SpeciesTumor MicroenvironmentTyrosineNitric OxidePeroxynitrous AcidReactive Nitrogen SpeciesReactive Oxygen SpeciesTyrosineCancerCysteine oxidationNitric oxidePeroxynitriteReactive nitrogen speciesTumor biologyTyrosine nitration

Identifiers

PMID42177837
PMCPMC13226151

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.