ArticleRenal failure2026
Potential circadian rhythm-related pathogenic genes in diabetic nephropathy: a multi-omics Mendelian randomization study.
Article in Renal failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
This study aims to identify pathogenic genes involved in diabetic nephropathy (DN) through multi-omics analysis of circadian rhythm disruptions to uncover targets for precision medicine. We conducted summary-data-based Mendelian Randomization (SMR) and colocalization analyses using multi-omics quantitative trait loci (QTL) data (methylation quantitative trait loci [mQTL] , expression quantitative trait loci [eQTL], protein quantitative trait loci [pQTL]) to explore genetic associations between circadian rhythm-related genes and DN. Genome-wide association study (GWAS) summary statistics were sourced from major consortia (discovery) and FinnGen (replication). Key gene expressions were validated in GEO (GSE96804). Transcription factors were predicted, and potential drugs (
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