Trial reportThe Journal of physiology2026
Artificial gravity during prolonged bed rest preserves resting metabolic rate but not muscle function: Evidence from the BRACE study.
Trial report in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
7 authors.
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Abstract
Prolonged head-down tilt bed rest induces metabolic and neuromuscular deconditioning. This study examined whether supine cycling exercise, with/without artificial gravity (AG), preserves resting metabolic rate (RMR) during 60 days of bed rest, and whether RMR responses align with integrated multivariate physiological adaptations. Twenty-four healthy men were randomly assigned to control (C), cycling (EX) or cycling plus AG (EX-AG). RMR, substrate oxidation, body composition (dual-energy X-ray absorptiometry/magnetic resonance imaging), muscle function and maximal cycling power were assessed before and after bed rest. Linear mixed models evaluated group-by-time effects. Principal component analysis (PCA) and sparse partial least squares (sPLS) regression examined multivariate correlates of ΔRMR. RMR responses differed between groups (interaction P = 0.029), with EX-AG preventing the decline observed in C (EX-AG vs. C ΔΔ = +133 kcal day
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Registered trials
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