Evidence map›Paper›PMID 42178479›Full record

ArticleBioresources and bioprocessing2026

ATP regeneration-driven biocatalytic production of 1,12-dodecanediol with improved cofactor supply.

Yoon Jung Jung, Gaeul Kim, Kyungjae Yu, Byung Wook Lee, Jung Bin Shin, Jung-Oh Ahn, Si Jae Park, See-Hyoung Park, Hyun Gi Koh, Kyungmoon Park

Abstract read
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In one paragraph

Article in Bioresources and bioprocessing, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yoon Jung JungDepartment of Biological and Chemical Engineering, Hongik University, Sejong, 30016, Republic of Korea.
Gaeul KimDepartment of Biological and Chemical Engineering, Hongik University, Sejong, 30016, Republic of Korea.
Kyungjae YuDepartment of Biological and Chemical Engineering, Hongik University, Sejong, 30016, Republic of Korea.
Byung Wook LeeDepartment of Biological and Chemical Engineering, Hongik University, Sejong, 30016, Republic of Korea.
Jung Bin ShinDepartment of Biological and Chemical Engineering, Hongik University, Sejong, 30016, Republic of Korea.
Jung-Oh AhnBiotechnology Process Engineering Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, 28116, Republic of Korea.
Si Jae ParkGraduate Program in System Health Science and Engineering, Department of Chemical Engineering and Materials Science, Ewha Womans University, Seoul, 03760, Republic of Korea.
See-Hyoung ParkDepartment of Biological and Chemical Engineering, Hongik University, Sejong, 30016, Republic of Korea. shpark74@hongik.ac.kr.
Hyun Gi KohDepartment of Biological and Chemical Engineering, Hongik University, Sejong, 30016, Republic of Korea. hgkoh@hongik.ac.kr.ORCID http://orcid.org/0000-0002-1348-1312
Kyungmoon ParkDepartment of Biological and Chemical Engineering, Hongik University, Sejong, 30016, Republic of Korea. pkm2510@hongik.ac.kr.

Funding

Hongik University Innovation Support program Hongik University Innovation Support programMinistry of Trade, Industry and Energy RS-2024-00432188Ministry of Trade, Industry and Energy RS-2025-02219753Ministry of Trade, Industry and Energy RS-2025-09312968Ministry of Trade, Industry and Energy RS-2025-13482968
6 · The paper itself

Abstract

1,12-Dodecanediol is a high-value chemical widely used in the polymer and fine chemical industries. However, its industrial production is currently based on petroleum-derived processes associated with high energy consumption and environmental concerns. To address these limitations, microbial bioconversion of 1,12-dodecanedioic acid (C12 diacid) to 1,12-dodecanediol (C12 diol) has been investigated as a sustainable production route. In this pathway, carboxylic acid reductase (CAR) requires ATP and NADPH as essential cofactors, making efficient cofactor supply an important factor for achieving high conversion efficiency. In this study, a recombinant Escherichia coli-based biocatalytic system was developed to enhance C12 diol production through ATP regeneration. ATP availability was identified as an important factor for whole-cell bioconversion, and a polyphosphate kinase 2 (PPK2) from Erysipelotrichaceae bacterium was introduced to regenerate ATP from AMP, increasing the conversion yield from 22.0% to 31.8% at 40 mM substrate. Supplementation with sodium hexametaphosphate (SHMP, polyP

Indexed as

1,12-DodecanediolATP regenerationBiocatalytic conversionCarboxylic acid reductasePolyphosphate kinase (PPK2)

Identifiers

PMID42178479
PMCPMC13199544

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.