Evidence map›Paper›PMID 42178489›Full record

ArticleMagnetic resonance in medicine2026

Multiecho Fat-Water Spiral MR Elastography With Distributed Encoding for Simultaneously Imaging Brain and Skull Displacement.

Alexa M Diano, Alex M Cerjanic, Olivia M Bailey, Mary K Kramer, Joy Mojumder, Ruth J Okamoto, Philip V Bayly, Dzung L Pham, Curtis L Johnson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alexa M DianoDepartment of Biomedical Engineering, University of Delaware, Newark, Delaware, USA.ORCID https://orcid.org/0000-0002-5941-5935
Alex M CerjanicDepartment of Biomedical Engineering, University of Delaware, Newark, Delaware, USA.
Olivia M BaileyDepartment of Biomedical Engineering, University of Delaware, Newark, Delaware, USA.ORCID https://orcid.org/0009-0008-9659-0223
Mary K KramerDepartment of Biomedical Engineering, University of Delaware, Newark, Delaware, USA.ORCID https://orcid.org/0000-0003-1305-9821
Joy MojumderThe Henry M Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA.
Ruth J OkamotoDepartment of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, Missouri, USA.
Philip V BaylyDepartment of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, Missouri, USA.
Dzung L PhamDepartment of Radiology and Bioengineering, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Curtis L JohnsonDepartment of Biomedical Engineering, University of Delaware, Newark, Delaware, USA.ORCID https://orcid.org/0000-0002-7760-131X

Funding

MRI Measurement of the Mechanical Vulnerability of the BrainU01NS112120 · NINDS · WASHINGTON UNIVERSITY · PI BAYLY, PHILIP V · 2019 to 2023
$3.7M
High-Resolution, Anisotropic MR Elastography of the BrainR01EB027577 · NIBIB · UNIVERSITY OF DELAWARE · PI BAYLY, PHILIP V, JOHNSON, CURTIS L · 2019 to 2022
$2.7M
Biomechanics of the Human Brain During High-Severity Impacts: A Multimodal ApproachR01NS136056 · NINDS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI Ahmed Alshareef, Matthew Brian Panzer · 2025 to 2026
$1.1M
Congressionally Directed Medical Research Programs W81XWH2211117NIBIB NIH HHS R01 EB027577NIH HHS Bench to BedsideNIH HHS R01-EB027577NIH HHS R01-NS136056NIH HHS U01-NS112120NINDS NIH HHS R01 NS136056NINDS NIH HHS U01 NS112120Office of Naval Research N00014-22-1-2198Office of Naval Research N00014-24-1-2599
6 · The paper itself

Abstract

purposeTo introduce a novel multiecho, multishot spiral MR elastography (MRE) sequence to image brain and skull displacement simultaneously using a joint fat-water image reconstruction and distributed motion encoding.

methodsMultiple echo times were implemented into a high-resolution multishot spiral MRE sequence to capture water-based brain signal and fat-based skull signal in a single acquisition. A joint fat-water reconstruction was optimized for brain-skull imaging, and a distributed motion encoding technique was incorporated to reduce acquisition time. This work demonstrates the feasibility of this sequence to quantify relative brain-skull displacement and brain tissue mechanical properties.

resultsBrain and skull displacement were successfully imaged in a single acquisition. This technique was validated through comparison to a reference EPI MRE scan in which no significant differences were found in mechanical properties derived from each scan. A preliminary analysis of brain and skull displacement over time revealed that relative brain-skull displacement was variable across the surface of the brain, with a higher amplitude of brain displacement at the anterior of the head.

conclusionThe proposed multiecho fat-water spiral MRE sequence is a promising technique for quantifying brain-skull displacement in vivo to improve computational modeling of traumatic brain injury.

Indexed as

Adipose TissueBrainElasticity Imaging TechniquesMagnetic Resonance ImagingSkullAlgorithmsHumansImage EnhancementImage Interpretation, Computer-AssistedReproducibility of ResultsSensitivity and Specificitybrainchemical shiftelastographyjoint reconstructionskull

Identifiers

PMID42178489
PMCPMC13420999

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.