Evidence map›Paper›PMID 42178558›Full record

ArticleBehavioral and brain functions : BBF2026

Knockout in zebrafish suggests a role of BDNF in behavioural and cognitive plasticity.

Eleonora Rovegno, Elia Gatto, Elena Frigato, Cristiano Bertolucci, Tyrone Lucon-Xiccato

Abstract read
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In one paragraph

Article in Behavioral and brain functions : BBF, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Eleonora RovegnoDepartment of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy. eleonora.rovegno@unife.it.
Elia GattoDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy.
Elena FrigatoDepartment of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.
Cristiano BertolucciDepartment of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.
Tyrone Lucon-XiccatoDepartment of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An adaptive mechanism observed in virtually all living animals is the phenotypic plasticity, a phenomenon by which different phenotypes can develop from the same genotype depending on the environment experienced. Phenotypic plasticity can involve a range of life-history, physiology, morphology, and also behavioural and cognitive traits. For example, individuals exposed to complex and enriched environments generally show greater learning abilities compared to individuals raised in simpler or barren environments. Several studies suggest that brain-derived neurotrophic factor (BDNF) may be involved in this plasticity, as it is often differentially expressed in individuals exposed to different environments. We investigated this possibility in fish, taking advantage of a knockout zebrafish line lacking the gene coding for BDNF (bdnf). Zebrafish from both the knockout (bdnf

Indexed as

Behavior, AnimalBrain-Derived Neurotrophic FactorCognitionNeuronal PlasticityZebrafish ProteinsAnimalsEnvironmentGene Knockout TechniquesPhenotypeZebrafishBDNF protein, zebrafishBrain-Derived Neurotrophic FactorZebrafish ProteinsEnvironmental enrichmentFish cognitionIndividual differencesNeural plasticityNeurotrophinsPhenotype plasticity

Identifiers

PMID42178558
PMCPMC13383490

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.