ArticleBJPsych open2026
Serotonin and working memory in mood disorder and healthy states: multi-cohort positron emission tomography study.
Article in BJPsych open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
8 authors.
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Abstract
backgroundWorking memory deficits are common in mood disorders and severely affect everyday functioning. Serotonin (5-HT) signalling has been implicated in depression and is also involved in cognitive functioning. However, its relevance for working memory remains largely unexplored.
aimsUsing positron emission tomography (PET) brain imaging, we investigated the link between working memory and multiple 5-HT brain features in both healthy individuals and patients with mood disorders in a cross-sectional analysis of pooled data-sets.
methodWe used multiple linear regression to test the associations between working memory performance and 5-HT 1B receptor (5-HT
resultsThere was no association between working memory and 5-HT
conclusionsWe found no evidence that key 5-HT receptor systems are associated with working memory performance in healthy individuals, but did observe a positive association for 5-HT
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