Novel antioxidant peptides from chicken bone hydrolysate: Identification, structure-activity relationship and cytoprotective effects against oxidative stress in HaCaT cells.

Yitong Jin, Juan Zhang, Junjian Miao, Zheng Peng, Yanan Liu, Zhijun Zhao

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In one paragraph

Article in Food chemistry: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

6 authors.

Yitong JinCollege of Environmental Science and Engineering, Donghua University, 2999 North Renmin Road, Shanghai 201620, China.

Juan ZhangKey Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, China.

Junjian MiaoCollege of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.

Zheng PengKey Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, China.

Yanan LiuCollege of Environmental Science and Engineering, Donghua University, 2999 North Renmin Road, Shanghai 201620, China.

Zhijun ZhaoLab of Biorefinery, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this study was to identify antioxidant peptides from chicken bone hydrolysate, elucidate their molecular mechanisms, and investigate their protective effects against oxidative damage in HaCaT cells. Four novel antioxidant peptides-SGQLSGPIRFF, LSGPIRFF, LIVYPW, and IFPVHWQF-were identified using nano-LC-MS/MS. Molecular docking results indicated that these peptides can interact with Keap1, indicating their potential involvement in the Keap1-Nrf2 signaling pathway. LIVYPW exhibits the highest E

Indexed as

Antioxidant peptidesChicken bone hydrolysateCytoprotective effectMolecular dockingQuantum chemistry

Identifiers

PMID42179952

DOI10.1016/j.fochx.2026.103962

PMCPMC13193779

What Socratic holds

Textmetadata

LicenceCC BY-NC-ND

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.