ArticlemedRxiv : the preprint server for health sciences2026
Systematic common and rare variant association testing in 392,030 whole genomes in
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In one paragraph
Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
50 authors.
Wenhan LuProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Robert J CarrollDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Matthew SolomonsonProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Jeremy GuezProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Megan K HeVanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA.
Daniel J MartenProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Alejandro Martinez-CarrascoProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Ying WangProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Connor S DowdProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Masahiro KanaiProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Bram L GorissenProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Aymone Jeanne S KouameVanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA.
James BroganDivision of Hospital Medicine, Department of Medicine, Johns Hopkins Hospital, Baltimore, MD, USA.
Bennett J WaxseNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Ryan SamarakoonVanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA.
Justin A CookVanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA.
Jun QianDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Yu ZhouCenter for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Karmel W ChoiCenter for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Melissa BasfordVanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA.
Michael LyonsVanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA.
Jodell E LinderVanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA.
Samantha StewartVanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA.
Namrata GuptaBroad Genomics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Patrick SchultzProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Daniel GoldsteinProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Christopher LlanwarneProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Jacqueline I GoldsteinProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Edmund G C HighamProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Daniel C KingProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Duncan S PalmerProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Jared S ElenbaasProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Gregory K RohlicekProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Qin HeProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Julia K GoodrichProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
All of Us Research Program Genomics Investigators
Jordan W SmollerStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Lee LichtensteinBroad Genomics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Stacey B GabrielBroad Genomics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Alicia R MartinProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Jason H KarnesDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Scott J HebbringMarshfield Clinic Health System, Marshfield, WI, USA.
Mark J DalyProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Tara DutkaAll of Us Research Program, Office of the Director, National Institutes of Health, Bethesda, MD, USA.
Anjene MusickAll of Us Research Program, Office of the Director, National Institutes of Health, Bethesda, MD, USA.
Joshua C DennyAll of Us Research Program, Office of the Director, National Institutes of Health, Bethesda, MD, USA.
Wei ZhouProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Dan M RodenDepartments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Benjamin M NealeAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Konrad J KarczewskiProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Funding
The Broad-LMM-Color Genome Center for All of UsOT2OD002750 · OD · BROAD INSTITUTE, INC. · PI GABRIEL, STACEY, REHM, HEIDI L · 2018 to 2023
$264.7MAll of Us Research Program Data and Research CenterOT2OD035404 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Melissa Basford, DAVID GLAZER · 2023 to 2026
$210.4MPrecision Medicine for All of Us Researchers Collective Medicine de Precision: Colectivo de Investigadores Salud para TodosOT2OD036485 · OD · UNIVERSITY OF ARIZONA · PI KARNES, JASON HANSEN, MORENO, FRANCISCO A · 2023 to 2025
$2.6MDeciphering respiratory disease mechanisms through integration of genomic and functional data across massive global biobanksR01HL179112 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Alicia Martin · 2025 to 2026
$1.6MNHLBI NIH HHS R01 HL179112NIH HHS OT2 OD002750NIH HHS OT2 OD035404NIH HHS OT2 OD036485
Abstract
Large-scale genome-wide association studies (GWAS) and rare variant association studies (RVAS) from population biobanks provide valuable resources for gene discovery in complex human traits. We present an analysis of the
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.