ArticleFrontiers in medicine2026
A retrospective analysis of paraquat and diquat poisoning: a single-center experience.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Paraquat (PQ) and diquat (DQ) are highly toxic bipyridyl herbicides, but their dominant organ injury patterns and clinical outcomes are not identical. This study aimed to compare the clinical characteristics, organ injury profiles, and prognosis of acute PQ and DQ poisoning. Methods: This retrospective single-center cohort study included consecutive patients with acute oral PQ or DQ poisoning treated at Guangzhou Occupational Disease Prevention and Treatment Hospital between January 2012 and January 2022. Baseline characteristics, clinical manifestations, admission laboratory findings, and in-hospital outcomes were compared between 270 patients with PQ poisoning and 115 patients with DQ poisoning. Results: PQ poisoning was associated with a higher crude in-hospital mortality rate than DQ poisoning (142/270 [52.6%] vs. 29/115 [25.2%], Conclusion: PQ and DQ poisoning show distinct clinical phenotypes and should not be managed as interchangeable toxic syndromes. Rapid toxin identification and toxin-specific monitoring may help guide early risk stratification and supportive care.
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