SynthesisFrontiers in medicine2026
Exercise intervention on sleep quality in Alzheimer's disease: a systematic review and meta-analysis.
Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Advancements in non-pharmaceutical interventions for Alzheimer's disease management: an update review.Frontiers in aging neuroscience · 2026Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Patients with Alzheimer's disease (AD) are often accompanied by severe sleep disorders, which exacerbate with disease progression. Currently, pharmacological treatments have limitations, and the effect of exercise as a non-pharmacological intervention on improving sleep quality in AD patients requires systematic evaluation. Methods: This study systematically searched six databases up to December 31, 2025, and included randomized controlled trials (RCTs) investigating the effects of exercise interventions on sleep quality in patients with Alzheimer's disease. Two researchers independently completed literature screening, data extraction, and risk of bias assessment. Data analysis and literature quality evaluation were performed using Review Manager 5.4 software, and effect sizes were pooled using standardized mean differences (SMD). Results: A total of 12 RCTs involving 893 patients were finally included. Meta-analysis results showed that exercise interventions significantly improved patients' subjective sleep quality, with a pooled effect size (SMD) of -0.81 for the Pittsburgh Sleep Quality Index (PSQI) score (95%CI: -1.55 to -0.06, Conclusion: Exercise interventions may improve subjective sleep quality in patients with Alzheimer's disease, with potentially greater benefits observed in those with more severe baseline sleep disturbances or exercise sessions lasting ≥1 h; however, their effects on objective sleep outcomes have not yet been fully established. Further large-scale studies with more rigorous methodology and combined subjective and objective assessments are needed to clarify the true benefits of exercise on sleep in patients with Alzheimer's disease and to determine the optimal intervention regimen. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251270397.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.