ReviewFrontiers in medicine2026
Intraoperative peripheral intravenous complications in adults: a summary of evidence for prevention and management of infiltration/extravasation.
Review in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To systematically synthesize the best available evidence and develop an evidence-based practice framework for the prevention, early identification, and management of intraoperative intravenous infusion complications, including non-cytotoxic drug infiltration and cytotoxic drug extravasation, in perioperative adult patients. Methods: Methodological standards for evidence summaries were strictly followed. Research questions were formulated using the PIPOST framework. Databases searched included PubMed, Embase, Web of Science, Cochrane Library, CNKI, Wanfang, SinoMed, VIP, and evidence-based platforms (UpToDate, BMJ Best Practice, JBI, GIN, NICE, RNAO). All sources were systematically searched from database inception to September 3, 2025. Following the 6S evidence pyramid, we prioritised guidelines, systematic reviews, expert consensuses, evidence summaries, and clinical decision tools over primary studies. Literature screening was conducted according to predefined inclusion and exclusion criteria. The quality of included clinical guidelines, systematic reviews, evidence summaries, expert consensus statements, and clinical decision tools was appraised using AGREE II, JBI critical appraisal tools, CASE checklists, and other appropriate instruments. Evidence was graded using the JBI evidence pre-grading system, and recommendation strength was classified as level A (strong) or level B (weak) through multidisciplinary expert consensus based on feasibility, appropriateness, clinical significance, and effectiveness. Results: Thirteen publications were included, comprising six clinical guidelines, three systematic reviews, one evidence summary, one expert consensus, and two clinical decision tools. A total of 41 evidence statements were extracted and synthesized into four thematic domains: prevention strategies; early identification and monitoring; treatment measures; and system management and improvement. Key areas included venous access planning, catheter and site selection, puncture techniques, safe administration of high-risk drugs, patient risk assessment, dynamic intraoperative monitoring principles, standardized assessment tools, and stepwise management protocols. System-level strategies such as adverse event reporting, staff training, quality improvement, and multidisciplinary collaboration were also emphasized. Conclusion: This evidence summary integrates current best evidence and provides a structured and practical framework for comprehensive perioperative management of intravenous infusion complications. Implementation of evidence-based strategies may enhance early risk detection and response, reduce complication incidence and severity, and ultimately improve patient safety and clinical outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.