Evidence map›Paper›PMID 42182115›Full record

ArticlebioRxiv : the preprint server for biology2026

Small extracellular vesicles mediate the antihyperalgesic effect of bone marrow stromal cells: the role of "priming".

Wei Guo, Jia-Le Yang, Huakun Xu, Kamal D Moudgil, Feng Wei, Ke Ren

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wei GuoDepartment of Neural and Pain Sciences, School of Dentistry, & Program in Neuroscience, University of Maryland, Baltimore, MD 21201, USA.
Jia-Le YangDepartment of Neural and Pain Sciences, School of Dentistry, & Program in Neuroscience, University of Maryland, Baltimore, MD 21201, USA.
Huakun XuDivision of Biomaterials and Tissue Engineering, School of Dentistry, University of Maryland, Baltimore, MD 21201, USA.
Kamal D MoudgilDepartment of Microbiology & Immunology, University of Maryland, Baltimore, MD 21201, USA.
Feng WeiDepartment of Neural and Pain Sciences, School of Dentistry, & Program in Neuroscience, University of Maryland, Baltimore, MD 21201, USA.
Ke RenDepartment of Neural and Pain Sciences, School of Dentistry, & Program in Neuroscience, University of Maryland, Baltimore, MD 21201, USA.ORCID 0000-0002-6485-1619

Funding

Disruption of Homeostatic Neuroimmune Interactions in Descending Circuitry in the Development of Pain ChronicityR01DE029946 · NIDCR · UNIVERSITY OF MARYLAND BALTIMORE · PI REN, KE, WEI, FENG · 2020 to 2024
$3.0M
Immune activation of the endogenous control of persistent painR01DE025137 · NIDCR · UNIVERSITY OF MARYLAND BALTIMORE · PI REN, KE · 2016 to 2020
$2.2M
Supraspinal mechanism of 5-HT-dependent descending facilitation in chronic painR01NS091296 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI WEI, FENG · 2015 to 2019
$1.7M
NIDCR NIH HHS R01 DE025137NIDCR NIH HHS R01 DE029946NINDS NIH HHS R01 NS091296
6 · The paper itself

Abstract

Multipotent mesenchymal stem cells (MSCs) including bone marrow stromal cells (BMSCs) have shown analgesic efficacy in recent years. Studies suggested that the therapeutic effect of MSCs was mediated by their secreted small extracellular vesicles (sEVs) mainly exosomes. The present study evaluated the antihyperalgesic effect of BMSC-related sEVs in a mouse model of neuropathic pain involving chronic constriction injury of the infraorbital nerve (CCI-ION). Our separation protocol generated EV particles mostly sized in the range of exosomes (30-170 nm) and express exosome marker proteins CD9, CD81, and Tsg101, suggesting their endosome origin. We show that intravenous injection of BMSC-related sEVs attenuated pain hypersensitivity induced by CCI-ION as indicated by decreased mechanical hypersensitivity (von Frey test) and reduced aversion to noxious stimulation (conditioned place avoidance test). The antihyperalgesic effect of sEVs was observed in both female and male animals, and the effect was dose-dependent. sEVs from

Indexed as

exosomesmesenchymal stromal cellsnerve injuryorofacialpainsmall extracellular vesicles

Identifiers

PMID42182115
PMCPMC13192723

What Socratic holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.