ArticlebioRxiv : the preprint server for biology2026
Hierarchical Interplay between H3K27ac and H3K4me3 in Transcriptional Regulation.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
H3K27ac and H3K4me3 are enriched at transcriptional start sites and have been implicated in transcription. However, how these marks concertedly regulate transcription is not fully understood. Here, we developed a dual chemically inducible CRISPR/dCas9-based epigenome editing system that enables independent, temporal and transcription stage-specific modulation of H3K27ac and H3K4me3 at a specific gene locus. Stage-specific removal of H3K4me3 impaired RNA polymerase II recruitment, increased promoter-proximal pausing, reduced productive elongation, and accelerates mRNA decay via increased m
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