In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
22 authors.
Victoria E DenekeResearch Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), 1030 Vienna, Austria.ORCID 0000-0002-4404-8706 Johannes P SuwitaResearch Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), 1030 Vienna, Austria.ORCID 0009-0007-7188-8376 Haoting WangDepartment of Experimental Genome Research, Research Institute for Microbial Diseases, The University of Osaka, Osaka 565-0871, Japan.ORCID 0009-0000-5176-7170 Shingo TonaiDepartment of Experimental Genome Research, Research Institute for Microbial Diseases, The University of Osaka, Osaka 565-0871, Japan.ORCID 0000-0003-0466-2450 Yonggang LuPremium Research Institute for Human Metaverse Medicine (WPI-PRIMe), The University of Osaka, Osaka 565-0871, Japan.ORCID 0000-0003-0198-8906 Karin PanserResearch Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), 1030 Vienna, Austria.
Alexander SchleifferResearch Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), 1030 Vienna, Austria.ORCID 0000-0001-6251-2747 Jeremy A HollisDivision of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, WA, United States of America.ORCID 0000-0003-3375-8937 Maria NovatchkovaResearch Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), 1030 Vienna, Austria.ORCID 0000-0002-8462-7171 Gerhard DürnbergerResearch Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), 1030 Vienna, Austria.ORCID 0000-0001-5059-5362 Karel StejskalInstitute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), 1030 Vienna, Austria.
Gabriela KrssakovaResearch Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), 1030 Vienna, Austria.
Andreas BlahaResearch Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), 1030 Vienna, Austria.ORCID 0000-0002-0995-4228 Aleq Adrianne R AndresanResearch Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), 1030 Vienna, Austria.
Muriel MirusResearch Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), 1030 Vienna, Austria.
Hana MarvanovaVienna BioCenter PhD Program, Doctoral School of the University of Vienna and Medical University of Vienna, Vienna, Austria.
Hsin-Yi ChangDepartment of Experimental Genome Research, Research Institute for Microbial Diseases, The University of Osaka, Osaka 565-0871, Japan.ORCID 0009-0008-9874-0483 Taichi NodaInstitute of Resource Development and Analysis, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto, Japan.ORCID 0000-0003-0260-7861 Alejandro BurgaInstitute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), 1030 Vienna, Austria.ORCID 0000-0002-0211-4357 Elisabeth RoitingerInstitute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), 1030 Vienna, Austria.ORCID 0000-0002-3405-7801 Masahito IkawaDepartment of Experimental Genome Research, Research Institute for Microbial Diseases, The University of Osaka, Osaka 565-0871, Japan.ORCID 0000-0001-9859-6217 Andrea PauliResearch Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), 1030 Vienna, Austria.ORCID 0000-0001-9646-2303 Funding
The Molecular Basis for Integrin-Mediated Bidirectional SignalingR35GM147414 · NIGMS · FRED HUTCHINSON CANCER CENTER · PI Melody G Campbell · 2022 to 2026
$2.2MNIGMS NIH HHS R35 GM147414
6 · The paper itselfAbstract
Fertilization requires gamete recognition and membrane fusion, yet the molecular basis of this process in vertebrates remains unknown. Here we identify SPARK (sperm protein assembly and receptor-binding key), a conserved multi-protein complex that integrates all known sperm fertilization factors, including TMEM81-IZUMO1-SPACA6 and DCST1/2, together with two newly identified components, TMDD1 and FAM187A. SPARK subunits are mutually dependent for stability in mature sperm, and disruption of any single component causes male sterility in zebrafish and mice. Incubating zebrafish sperm with soluble egg receptor Bouncer partially rescues fertilization of Bouncer-deficient eggs in a SPARK-dependent manner, consistent with egg receptor binding priming the complex for fusion. Thus, we propose SPARK as a conserved molecular machine that couples gamete recognition to membrane fusion.
Indexed as
AlphaFold structural predictionsfertilizationgamete recognitionmembrane fusionmousereproductive biologysperm-egg interactionzebrafish
Identifiers
PMID42182320
PMCPMC13192892
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
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