Evidence map›Paper›PMID 42182419›Full record

ArticlebioRxiv : the preprint server for biology2026

Composite Certainty: Addressing Metric Degeneracy in Parameter Inference for Model-Based Diagnostics.

Amruta Koshe, Ehsan Sobhani Tehrani, Kian Jalaleddini, Hamid Motallebzadeh

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Amruta KosheiKinesia Inc., Montreal, QC, J4W 1Y4, Canada.
Ehsan Sobhani TehraniiKinesia Inc., Montreal, QC, J4W 1Y4, Canada.ORCID 0000-0002-9539-9952
Kian JalaleddiniiKinesia Inc., Montreal, QC, J4W 1Y4, Canada.ORCID 0000-0002-1545-158X
Hamid MotallebzadehDepartment of Communication Sciences and Disorders, California State University, Sacramento, CA, 95819, USA.ORCID 0000-0003-3390-5263

Funding

Objective and noninvasive diagnosis of middle-ear and conductive pathologies using simulation-based inference and transfer learning applied to clinical dataR21DC020274 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI MOTALLEBZADEH, HAMID · 2022 to 2024
$549k
NIDCD NIH HHS R21 DC020274
6 · The paper itself

Abstract

Quantifying the diagnostic dispersion of inferred parameter distributions is a challenge in uncertainty-aware modeling. Scalar summaries such as credible interval width are topology-blind; fundamentally different posterior morphologies can yield identical scores, obscuring whether a parameter is precisely estimated or constrained to a range. We propose a Composite Certainty Framework that addresses this metric degeneracy by aggregating five complementary uncertainty metrics including interquartile range, standard deviation, full width at half maximum, Shannon entropy, and mass width. These metrics are aggregated through non-parametric Borda rank voting into a single, unitless consensus certainty score. Applied to a simulation-based inference pipeline for a finite-element model of the human middle ear tuned to cadaveric acoustic measurements, the framework reveals parameter-specific identifiability profiles invisible to any individual metric. It produces two actionable clinical thresholds: (1) the maximum tolerable measurement noise for reliable parameter recovery, and (2) the minimum simulation budget for posterior convergence. We demonstrated that no single metric captures all aspects of posterior dispersion, as spread-based metrics and entropy diverge systematically for clinically critical parameters, whereas their aggregation produces a consensus reflecting genuine diagnostic certainty. The framework is generalizable to any model-based diagnostic pipeline where posterior distribution not merely its coverage, but determines clinical certainty.

Identifiers

PMID42182419
PMCPMC13192612

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.