Evidence map›Paper›PMID 42182872›Full record

ArticleMaterials today. Bio2026

Multidimensional nano-ion composite hydrogel based on enzymatic blood glucose control, gas therapy and ion liquid permeation for repairing diabetic wounds.

Jun Ren, Peng Chen, Chun Sun, Hao Gao, Chenyu Li, Fangzheng Wang, Yuan Zhai, Yuting Zhang, Wen Luo, Chaoli Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jun RenDepartment of Orthopedics, Tangdu Hospital, The Fourth Military Medical University, 1 Xinsi Rd, Xi'an, Shaanxi, 710038, China.
Peng ChenDepartment of Thoracic Surgery, Xijing 986 Hospital, The Fourth Military Medical University, 269 Youyidong Rd, Xi'an, Shaanxi, 710054, China.
Chun SunDepartment of Orthopedics, Tangdu Hospital, The Fourth Military Medical University, 1 Xinsi Rd, Xi'an, Shaanxi, 710038, China.
Hao GaoDepartment of Orthopedics, Tangdu Hospital, The Fourth Military Medical University, 1 Xinsi Rd, Xi'an, Shaanxi, 710038, China.
Chenyu LiDepartment of Orthopedics, Tangdu Hospital, The Fourth Military Medical University, 1 Xinsi Rd, Xi'an, Shaanxi, 710038, China.
Fangzheng WangDepartment of Orthopedics, Tangdu Hospital, The Fourth Military Medical University, 1 Xinsi Rd, Xi'an, Shaanxi, 710038, China.
Yuan ZhaiDepartment of Pharmacy, The Fourth Military Medical University, Shaanxi Key Laboratory of Chiral Drug and Vaccine Adjuvants, 169 Changlexi Rd, Xi'an, Shaanxi,710032, China.
Yuting ZhangDepartment of Pharmacy, The Fourth Military Medical University, Shaanxi Key Laboratory of Chiral Drug and Vaccine Adjuvants, 169 Changlexi Rd, Xi'an, Shaanxi,710032, China.
Wen LuoDepartment of Ultrasonography, Xijing Hospital, The Fourth Military Medical University, 169 Changlexi Rd, Xi'an, Shaanxi, 710032, China.
Chaoli WangDepartment of Pharmacy, The Fourth Military Medical University, Shaanxi Key Laboratory of Chiral Drug and Vaccine Adjuvants, 169 Changlexi Rd, Xi'an, Shaanxi,710032, China.
Yunfei ZhangDepartment of Orthopedics, Tangdu Hospital, The Fourth Military Medical University, 1 Xinsi Rd, Xi'an, Shaanxi, 710038, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The multifactorial pathogenesis of diabetic foot ulcers (DFUs) poses significant challenges to effective clinical management. To address this complexity, we have developed a multi-functional ionic composite hydrogel designed to concurrently target four key pathological factors of diabetic wounds. The system integrates: (1) hollow mesoporous silica nanoparticles (HMSNs) encapsulating glucose oxidase (GOx), which protect the enzyme from inactivation in the hyperglycemic and inflammatory wound microenvironment, enabling sustained glucose regulation; (2) L-arginine (LArg), which reacts with the hydrogen peroxide (H

Indexed as

Diabetic wound healingHydrogelsIonic liquidSilica nanoparticle

Identifiers

PMID42182872
PMCPMC13194551

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.