Evidence map›Paper›PMID 42182875›Full record

ArticleMaterials today. Bio2026

Smart immunomodulatory polysaccharide hydrogels promote diabetic bone regeneration by regulating the inflammation-angiogenesis-osteogenesis axis.

Nanning Lv, Haifu Sun, Xiaofan Chen, He Dong, Wenxiang Tang, Yifeng Jiang, Lihui Hong, Hongye Li, Yusen Qiao, Xieping Dong and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nanning LvDepartment of Orthopaedics, Lianyungang Clinical College, Xuzhou Medical University & the Second People's Hospital of Lianyungang, Bengbu Medical University & the Second People's Hospital of Lianyungang, Lianyungang 222003, China.
Haifu SunDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Xiaofan ChenJXHC Key Laboratory of Digital Orthopedics, Jiangxi Provincial People's Hospital (The First Affiliated Hospital of Nanchang Medical College), Nanchang Key Laboratory of Medical 3D Printing Innovation and Translation, Nanchang 330006, China.
He DongDepartment of Orthopaedic Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200000, China.
Wenxiang TangDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Yifeng JiangJXHC Key Laboratory of Digital Orthopedics, Jiangxi Provincial People's Hospital (The First Affiliated Hospital of Nanchang Medical College), Nanchang Key Laboratory of Medical 3D Printing Innovation and Translation, Nanchang 330006, China.
Lihui HongDepartment of Orthopaedics, Lianyungang Clinical College, Xuzhou Medical University & the Second People's Hospital of Lianyungang, Bengbu Medical University & the Second People's Hospital of Lianyungang, Lianyungang 222003, China.
Hongye LiDepartment of Orthopaedics, Lianyungang Clinical College, Xuzhou Medical University & the Second People's Hospital of Lianyungang, Bengbu Medical University & the Second People's Hospital of Lianyungang, Lianyungang 222003, China.
Yusen QiaoDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Xieping DongJXHC Key Laboratory of Digital Orthopedics, Jiangxi Provincial People's Hospital (The First Affiliated Hospital of Nanchang Medical College), Nanchang Key Laboratory of Medical 3D Printing Innovation and Translation, Nanchang 330006, China.
Mingming LiuDepartment of Orthopaedics, Lianyungang Clinical College, Xuzhou Medical University & the Second People's Hospital of Lianyungang, Bengbu Medical University & the Second People's Hospital of Lianyungang, Lianyungang 222003, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic bone defects (DBD) are refractory to repair because chronic inflammation, excessive reactive oxygen species (ROS), and insufficient microangiogenesis disrupt immune, vascular, and osteogenic coupling. Here, we report a smart immune polysaccharide hydrogel (HCSO@ZL) that restores this axis through controlled Zn

Indexed as

Diabetic bone defect (DBD)Immune polysaccharide hydrogelMacrophage polarizationReactive oxygen

Identifiers

PMID42182875
PMCPMC13196100

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.