Evidence map›Paper›PMID 42183023›Full record

ReviewNon-coding RNA research2026

Functional role of long non-coding RNA MALAT1 and HOTAIR in lung cancer.

Hong-Wei Wen, Ali Afzal, Guang-Wei Chen, Ghazala Saeed, Yang An, Shi-Chang Sun, Amna Rehman, Muhammad Usman Jamil, Umair Ali Khan Saddozai, Lei Zhang and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Non-coding RNA research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hong-Wei WenDepartment of Public Health, Zhengzhou Health College, Zhengzhou, Henan, 450000, China.
Ali AfzalUniversity of Chinese Academy of Sciences, Beijing, 100049, China.
Guang-Wei ChenDepartment of Pulmonary and Critical Care Medicine, People's Hospital of Fangcheng County, Nanyang, Henan, 473200, China.
Ghazala SaeedSchool of Basic Medical Sciences & School of Public Health, Faculty of Medicine, Yangzhou University, Yangzhou, 225009, China.
Yang AnDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Henan University, Kaifeng, 475004, China.
Shi-Chang SunDepartment of Pulmonary and Critical Care Medicine, People's Hospital of Fangcheng County, Nanyang, Henan, 473200, China.
Amna RehmanInstitute of Zoology, University of the Punjab, Lahore, Pakistan.
Muhammad Usman JamilUniversity of Chinese Academy of Sciences, Beijing, 100049, China.
Umair Ali Khan SaddozaiSchool of Basic Medical Sciences & School of Public Health, Faculty of Medicine, Yangzhou University, Yangzhou, 225009, China.
Lei ZhangHenan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, Henan, 475004, China.
Fang MaDepartment of Medicine, People's Hospital of Fangcheng County, Fangcheng County, Nanyang City, Henan, 473200, China.
Xin-Ying JiFaculty of Basic Medical Subjects, Shu-Qing Medical College of Zhengzhou, Mazhai, Erqi District, Zhengzhou, Henan, 450064, China.
Muhammad Babar KhawarSchool of Basic Medical Sciences & School of Public Health, Faculty of Medicine, Yangzhou University, Yangzhou, 225009, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long noncoding RNAs, particularly MALAT1 and HOTAIR, play a key role in regulating tumorigenesis, and therapeutic response. Current literature indicates their influence on key oncogenic pathways. Yet, the literature remains fragmented and lacks context-dependent roles. A clearer understanding of the mechanisms, and downstream targets is, therefore, warranted. Herein, we provide an updated synthesis that integrates scattered findings on MALAT1 and HOTAIR that have not been addressed in prior studies. We aim to summarize the oncogenic mechanisms of MALAT1 and HOTAIR in lung cancer and evaluate their roles in chemoresistance, metastasis, and immune modulation with an emphasis on their diagnostic and translational potential.

Indexed as

ChemoresistanceHOTAIRLong noncoding RNAsLung cancerMALAT1

Identifiers

PMID42183023
PMCPMC13196394

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.