Evidence map›Paper›PMID 42183148›Full record

ArticleScientifica2026

Can Persistent Blue Light Exposure Cause a Molecular Shift in the Vitreous of Rodents?

Nagarajan Theruveethi, Manjunath B Joshi, Manna Valiathan, Radhika R P, Shama Prasada Kabekkodu, Shailaja Bhat

Abstract read
In one paragraph

Article in Scientifica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nagarajan TheruveethiDepartment of Optometry, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India, manipal.edu.ORCID https://orcid.org/0000-0003-1028-5807
Manjunath B JoshiDepartment of Ageing Research, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India, manipal.edu.ORCID https://orcid.org/0000-0002-1310-5480
Manna ValiathanDepartment of Pathology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India, manipal.edu.ORCID https://orcid.org/0000-0003-3496-9920
Radhika R PDepartment of Optometry, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India, manipal.edu.ORCID https://orcid.org/0000-0002-9786-0634
Shama Prasada KabekkoduDepartment of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India, manipal.edu.ORCID https://orcid.org/0000-0002-4158-3893
Shailaja BhatDepartment of Ophthalmology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India, manipal.edu.ORCID https://orcid.org/0000-0002-8273-3755

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This experimental rodent study aimed to explore changes in the vitreous metabolome caused by prolonged chronic environmental blue light stress and to elucidate the underlying mechanisms. Four separate groups of control (NC), blue light (LE), two blue blocking lenses (blue light-blocking lenses (BBLs), BL + Crizal Prevencia (CP) and BL+Duravision Blue protect (DP) and 8-week-old albino male Wistar rats were used in this experiment. Animals were subjected to blue LED light, with and without BBLs, for 90 days under a 12:12-h light:dark cycle and constant illumination at 450-500 lux. The control animals were maintained in standard laboratory conditions. Postexposure, the vitreous fluid (VF) was aspirated, stored at -20°C, and processed for LC-MS. We observed significant variation in amino acid (AA) abundance across four groups: normal control (NC), light exposure (LE), light exposure with Duravision Blue (DB) and light exposure with CP lenses. Specifically, there was a significant difference in AA content between NC and LE [

Indexed as

amino acidsblue light blocking lensesmass spectrometrymetabolitesshort wavelength

Identifiers

PMID42183148
PMCPMC13197830

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.