Evidence map›Paper›PMID 42183154›Full record

ArticleCell biomaterials2026

Nanoparticle induction of antigen-presenting monocyte-derived dendritic cells relieves immunosuppression and inhibits metastasis.

Jeffrey A Ma, Kate V Griffin, Kathryn Kang, Agustina Diener, Ian A Schrack, Elizabeth J Bealer, Laila M Rad, Rebecca S Pereles, Jacqueline S Jeruss, Lonnie D Shea

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jeffrey A MaDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Ann Arbor, MI 48109, USA.
Kate V GriffinDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Ann Arbor, MI 48109, USA.
Kathryn KangDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Ann Arbor, MI 48109, USA.
Agustina DienerDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Ann Arbor, MI 48109, USA.
Ian A SchrackDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Ann Arbor, MI 48109, USA.
Elizabeth J BealerDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Ann Arbor, MI 48109, USA.
Laila M RadDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Ann Arbor, MI 48109, USA.
Rebecca S PerelesDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Ann Arbor, MI 48109, USA.
Jacqueline S JerussDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Ann Arbor, MI 48109, USA.
Lonnie D SheaDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Ann Arbor, MI 48109, USA.

Funding

Nanoparticle-mediated reprogramming of circulating monocytes and neutrophils to decrease inflammation-mediated damage after traumaR01AI148076 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANDERSON, AILEEN J, SHEA, LONNIE D · 2019 to 2023
$3.4M
Identifying intercellular circuits driving cell phenotypes within a nicheR01CA243916 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JERUSS, JACQUELINE SARA, SHEA, LONNIE D · 2019 to 2023
$2.3M
Tissue engineering tools for monitoring the cellular and molecular response to therapyR01CA272940 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JACQUELINE SARA JERUSS, Lonnie D Shea · 2023 to 2026
$1.7M
Nanoparticles to reprogram innate immune cells and disrupt the metastatic nicheR01EB036030 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JACQUELINE SARA JERUSS, Lonnie D Shea · 2024 to 2026
$1.5M
NCI NIH HHS R01 CA243916NCI NIH HHS R01 CA272940NIAID NIH HHS R01 AI148076NIBIB NIH HHS R01 EB036030
6 · The paper itself

Abstract

Myeloid immune cells play a major role in establishing a suitable microenvironment for metastasis by suppressing antigen-presentation pathways and effector T cell responses at metastatic sites, and reprogramming these cells may enhance anti-tumor cytotoxicity. Herein, we target myeloid cells with intravenously delivered nanoparticles to reduce the accumulation of neutrophils at the metastatic niche and induce the differentiation of monocytes into monocyte-derived dendritic cells (moDCs). Internalization of nanoparticles was linked to increased antigen presentation, T cell stimulation, and activation of Th1 cells. Nanoparticle administration increased the proportion of Th1 and Th17 CD4

Identifiers

PMID42183154
PMCPMC13197090

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.