ArticleNational science review2026
Ultrasound-sensitive microrobotic sensor with robust anchoring for long-term digestive lesion assessment.
Article in National science review, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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17 authors.
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Abstract
Microrobots have achieved notable progress in targeted drug delivery for treating various diseases. However, employing the microrobot itself as a microsensor for remote and long-term lesion assessment remains challenging. Here, we design a bioinspired ultrasound-sensitive microrobotic sensor (USMS) capable of robust anchoring for wireless and long-term digestive disease treatment and assessment. The USMS integrates dual magnetic and focused ultrasound actuation for precise locomotion and on-demand drug delivery, while a bioinspired microneedle design secures stable anchoring against strong fluid flow (402 mm/s) and peristaltic forces (66.5 mN). More importantly, the air cavity design of USMS enables strong ultrasound reflection for remote and long-term sensing of protruding lesion radius to assess therapeutic efficacy. Overall, USMS demonstrates reliable on-demand drug delivery and lesion size sensing capabilities in mouse models. The USMS has the potential to serve as a versatile robotic platform and sensing system for monitoring lesion evolution in clinical disease management.
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