ArticleFrontiers in immunology2026
Grape seed proanthocyanidins supplementation attenuates diquat-induced intestinal barrier damage in weaned pigs.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Grape seed proanthocyanidins (GSP) is a kind of plant polyphenols with a wide variety of biological activities. In the present study, we evaluated whether GSP can alleviate intestinal injury in weaned pigs injected with diquat. Methods: A total of 32 pigs were randomly assigned to four groups (n = 8): (1) nonchallenged control; (2) control + 50 mg/kg GSP; (3) diquat-treated control and (4) diquat + 50 mg/kg GSP. On the morning of day 15, the pigs were injected with diquat (10 mg per kg body weight) or saline, and were then killed to obtain the serum and intestinal segments 7 days later. Results: The results showed that GSP addition decreased ( Conclusion: These findings suggest that GSP can attenuate diquat-induced intestinal mucosa disruption, which was linked to enhancement of the antioxidant capacity and improvement in intestinal microbiota.
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