Research advances in the identification of gut keystone bacteria and formulation of suitable dietary intervention strategies for restoring gut homeostasis.

Qiang Meng, Huimin Zhang, Jianming Ye, Ting Liu, Yihua Li, Wei Song, Yane Luo, Tianli Yue

Abstract readReview

In one paragraph

Review in NPJ biofilms and microbiomes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qiang Meng *College of Food Science and Technology, Northwest University, Xi'an, Shaanxi, China.

Huimin Zhang *College of Food Science and Technology, Northwest University, Xi'an, Shaanxi, China.

Jianming Ye *College of Life Science and Agri-forestry, Southwest University of Science and Technology, Mianyang, Sichuan, China.

Ting LiuCollege of Food Science and Technology, Northwest University, Xi'an, Shaanxi, China.

Yihua LiThe Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.

Wei SongCollege of Food Science and Technology, Northwest University, Xi'an, Shaanxi, China.

Yane LuoCollege of Food Science and Technology, Northwest University, Xi'an, Shaanxi, China. luoyane@nwu.edu.cn.ORCID http://orcid.org/0000-0002-0273-1195

Tianli YueCollege of Food Science and Technology, Northwest University, Xi'an, Shaanxi, China.

Funding

Innovation Capability Support Plan Project in Shaanxi Province 2024RS-CXTD-76Natural Science Basic Research Program of Shaanxi Province 2024JC-YBQN-0218Xi'an Science and Technology Plan Project 24NYGG0028

6 · The paper itself

Abstract

Methodological inconsistencies hinder the identification of gut keystone bacteria and their functional mechanisms. This work critically compares identification approaches, elucidates their interactions within the microbiota and host, and systematically details targeted dietary interventions. By explicitly linking keystone identification to diet-driven modulation, it provides a practical and precise framework for developing gut health strategies and managing microbiota-related diseases.

Indexed as

BacteriaDietGastrointestinal MicrobiomeGastrointestinal TractAnimalsHomeostasisHumans

Identifiers

PMID42185282

DOI10.1038/s41522-026-01020-9

PMCPMC13483174

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.