Evidence map›Paper›PMID 42185568›Full record

ArticleMolecular neurobiology2026

Ghrelin Ameliorates Alzheimer's Disease-Associated Astrocyte Dysfunction via UCP2-Mediated Inhibition of FOXO1 Nuclear Translocation.

Yaoxue Guo, Xueyan Wang, Lixiang Zhang, Xing Liu, Pu Lu, Furu Liang, Jing Wu, Junli Zhao, Yan Hai

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yaoxue GuoDepartment of Clinical Pharmacy, Baotou Central Hospital, 61 Huancheng Road, Donghe District, Baotou, 014040, Inner Mongolia, China.
Xueyan WangOncology Department, Baotou Central Hospital, Baotou, 014040, Inner Mongolia, China.
Lixiang ZhangDepartment of Clinical Pharmacy, Baotou Central Hospital, 61 Huancheng Road, Donghe District, Baotou, 014040, Inner Mongolia, China.
Xing LiuPharmacy Department, Baotou Central Hospital, Baotou, 014040, Inner Mongolia, China.
Pu LuOncology Department, Baotou Central Hospital, Baotou, 014040, Inner Mongolia, China.
Furu LiangDepartment of Neurology, Baotou Central Hospital, Baotou, 014040, Inner Mongolia, China.
Jing WuPharmacy Department, Baotou Central Hospital, Baotou, 014040, Inner Mongolia, China.
Junli ZhaoPharmacy Department, Baotou Central Hospital, Baotou, 014040, Inner Mongolia, China. 18604729668@163.com.
Yan HaiPharmacy Department, Baotou Central Hospital, Baotou, 014040, Inner Mongolia, China. 13354726859@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is associated with mitochondrial dysfunction and impaired energy metabolism in astrocytes. Although ghrelin is known to exert neuroprotective effects, the mechanisms through which it modulates astrocyte bioenergetics under AD-like conditions remain incompletely defined. In primary astrocytes treated with Aβ

Indexed as

Alzheimer DiseaseAstrocytesCell NucleusForkhead Box Protein O1GhrelinUncoupling Protein 2Amyloid beta-PeptidesAnimalsGlycolysisMaleMembrane Potential, MitochondrialMice, Inbred C57BLMitochondriaPeptide FragmentsAmyloid beta-Peptidesamyloid beta-protein (25-35)Forkhead Box Protein O1GhrelinPeptide FragmentsUcp2 protein, mouseUncoupling Protein 2Alzheimer’s diseaseAstrocyteGhrelinGlycolysisMitochondrial dysfunctionUCP2-FOXO1 pathway

Identifiers

PMID42185568

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.