Evidence map›Paper›PMID 42186216›Full record

ArticleCancer science2026

Epithelial YPEL3 Modulates CD8

Yalun Li, Yumei Li, Caiyu Sun, Congxian Lu, Gang Chen, Tianshu Zhou, Bei Zhang, Xicheng Song

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yalun LiDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China.
Yumei LiDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China.
Caiyu SunDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China.
Congxian LuDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China.
Gang ChenDepartment of Breast Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China.ORCID https://orcid.org/0000-0003-2541-806X
Tianshu ZhouDepartment of Breast Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China.
Bei ZhangSchool of Basic Medicine, Qingdao University, Yantai, China.
Xicheng SongDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China.ORCID https://orcid.org/0000-0002-9789-1318

Funding

China Postdoctoral Science Foundation 2025M772104National Natural Science Foundation of China 82503561Natural Science Foundation of Shandong Province ZR2023QH108Special Clinical Research Grant of the Wu Jieping Medical Foundation 3206750202318104
6 · The paper itself

Abstract

Yippee-like 3 (YPEL3) has been implicated in the regulation of apoptosis, proliferation, and invasion in various cancers, but its role in head and neck squamous cell carcinoma (HNSCC) remains unclear. Here, we integrated pan-cancer data, TCGA/GEO transcriptomes, DNA methylation profiles, and single-cell RNA sequencing to explore YPEL3's expression, prognosis, and immune relevance in HNSCC. YPEL3 was downregulated in tumor tissues and correlated with better overall survival, particularly in advanced-stage patients. Functional assays confirmed that YPEL3 suppressed proliferation, migration, and invasion while promoting apoptosis in vitro; its knockdown accelerated tumor growth in vivo. Bulk transcriptomics and TIMER analysis revealed that high YPEL3 expression was associated with increased stromal and immune infiltration, including CD8

Indexed as

CD8-Positive T-LymphocytesChemokine CXCL16Cyclic AMP Response Element-Binding ProteinHead and Neck NeoplasmsSquamous Cell Carcinoma of Head and NeckAnimalsCell Line, TumorCell MovementCell ProliferationDisease ProgressionGene Expression Regulation, NeoplasticHumansLymphocytes, Tumor-InfiltratingMicePrognosisReceptors, CXCR6Chemokine CXCL16CXCR6 protein, humanCyclic AMP Response Element-Binding ProteinReceptors, CXCR6CXCL16–CXCR6 axisepithelial–immune crosstalkHNSCCtumor immune microenvironmentYPEL3

Identifiers

PMID42186216
PMCPMC13394896

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.