Evidence map›Paper›PMID 42187111›Full record

ArticleOrganic & biomolecular chemistry2026

Linker dependence of

Çetin Çelik, Naoko Kakusho, Tianyu Xu, Sung Sik Lee, Naoko Yoshizawa-Sugata, Hisao Masai, Yoko Yamakoshi

Abstract read
In one paragraph

Article in Organic & biomolecular chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Çetin ÇelikDepartment of Chemistry and Applied Biosciences, ETH Zürich, Vladimir-Prelog-Weg 3, CH-8093 Zürich, Switzerland. yamakoshi@org.chem.ethz.ch.ORCID 0000-0001-6132-8710
Naoko KakushoDepartment of Basic Medical Sciences, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya, Tokyo 156-8506, Japan. masai-hs@igakuken.or.jp.ORCID 0009-0009-2957-3930
Tianyu XuDepartment of Chemistry and Applied Biosciences, ETH Zürich, Vladimir-Prelog-Weg 3, CH-8093 Zürich, Switzerland. yamakoshi@org.chem.ethz.ch.ORCID 0009-0004-6453-2038
Sung Sik LeeScopeM, ETH Zürich, Otto-Stern-Weg 3, CH-8093 Zürich, Switzerland.ORCID 0000-0001-9267-232X
Naoko Yoshizawa-SugataResearch Center for Genome & Medical Sciences, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya, Tokyo 156-8506, Japan. yoshizawa-nk@igakuken.or.jp.ORCID 0000-0001-8792-8669
Hisao MasaiDepartment of Basic Medical Sciences, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya, Tokyo 156-8506, Japan. masai-hs@igakuken.or.jp.ORCID 0000-0003-1268-5302
Yoko YamakoshiDepartment of Chemistry and Applied Biosciences, ETH Zürich, Vladimir-Prelog-Weg 3, CH-8093 Zürich, Switzerland. yamakoshi@org.chem.ethz.ch.ORCID 0000-0001-8466-0118

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Three water-soluble porphyrins with tetracationic imidazolium groups were synthesized and assessed for complexation with human telomeric guanine-quadruplex (G4) DNA. Based on UV-vis titration studies, these porphyrins showed 10-fold higher complexation stability toward G4 DNA over non-G4 DNA. This was consistent with FRET experimental data, which showed that G4 stabilization by these porphyrins was significantly enhanced in comparison with that of non-G4 DNA. The porphyrins had slightly longer absorption wavelengths than a previously reported cationic porphyrin with the same functional groups but shorter linkers, indicating that they may be more suitable as photosensitizers (PSs) for photodynamic therapy (PDT). Significant photoinduced singlet oxygen (

Indexed as

DNAG-QuadruplexesImidazolesPhotosensitizing AgentsPorphyrinsSinglet OxygenHeLa CellsHumansMolecular StructureDNAImidazolesPhotosensitizing AgentsPorphyrinsSinglet Oxygen

Identifiers

PMID42187111
PMCPMC13203353

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.