ArticleBiosensors2026
Ultrasensitive Label-Free Detection of Free Thyroxine (T4) in Physiological Ranges Using Aptamer-Functionalized Silicon Nanowire Field Effect Transistors.
Article in Biosensors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Thyroxine (T4) is a key hormone regulating metabolic, cardiovascular, and neurodevelopmental processes, yet its clinical quantification still relies on centralized immunoassays that limit rapid or point-of-care monitoring. Here, we present a label-free biosensing platform based on silicon nanowire field-effect transistors (SiNW-FETs) functionalized with a T4-selective DNA aptamer via a 3-Triethoxysilyl propylsuccinic Anhydride (TESPSA)-mediated silanization approach, enabling a streamlined two-step modification for oriented immobilization. The biosensor achieves robust real-time detection of T4 across the physiological concentration range (5-30 pM), with a limit of detection of ~5 pM and a strong linear correlation between drain current and analyte concentration (R
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