Evidence map›Paper›PMID 42188414›Full record

ReviewJournal of functional biomaterials2026

Effectiveness of β-TriCalcium Phosphate for Alveolar Ridge Preservation: A Systematic Review.

Vitolante Pezzella, Andrea Blasi, Leopoldo Mauriello, Giuseppe Trapanese, Elio Ramaglia, Michele Basilicata, Vincenzo Iorio-Siciliano, Luca Ramaglia

Abstract readReview
In one paragraph

Review in Journal of functional biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Vitolante PezzellaDepartment of Periodontology, School of Dental Medicine, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0001-5116-3270
Andrea BlasiDepartment of Periodontology, School of Dental Medicine, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0003-4791-8794
Leopoldo MaurielloDepartment of Periodontology, School of Dental Medicine, University of Naples Federico II, 80131 Naples, Italy.ORCID 0009-0000-4723-3360
Giuseppe TrapaneseDepartment of Neuroscience, Reproductive Science and Dentistry, University of Naples Federico II, 80131 Naples, Italy.ORCID 0009-0002-7283-3012
Elio RamagliaDepartment of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy.ORCID 0009-0007-8036-9738
Michele BasilicataUOSD Special Care Dentistry, Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, 00133 Rome, Italy.
Vincenzo Iorio-SicilianoDepartment of Periodontology, School of Dental Medicine, University of Naples Federico II, 80131 Naples, Italy.
Luca RamagliaDepartment of Periodontology, School of Dental Medicine, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0003-1121-121X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alveolar ridge preservation (ARP) aims to reduce post-extraction bone resorption and facilitate implant placement. Among alloplastic grafts, β-tricalcium phosphate (β-TCP) is widely used due to its osteoconductive properties and complete resorbability. This systematic review evaluated the clinical effectiveness of β-TCP for ARP, focusing on ridge dimensional changes assessed by cone-beam computed tomography (CBCT). Electronic searches were performed in major scientific databases up to April 2026. Randomized controlled trials (RCTs) reporting CBCT-based dimensional outcomes after at least 4 months were included. Five RCTs met the inclusion criteria. Considerable heterogeneity was observed in biomaterial formulations, socket management, and outcome assessment. When used alone, β-TCP showed variable results, ranging from greater ridge resorption compared with xenograft to outcomes comparable with those of freeze-dried bone allograft. More consistent findings were reported when β-TCP was used in combination with other biomaterials, with outcomes generally comparable to those of deproteinized bovine bone mineral (DBBM). Overall, β-TCP may have a potential role in alveolar ridge preservation; however, evidence remains limited and heterogeneous. Differences between β-TCP alone and composite formulations should be carefully considered, and no definitive conclusions can be drawn regarding its comparative predictability versus xenografts. Further RCTs are needed to clarify its clinical effectiveness and identify optimal applications.

Indexed as

beta-tricalcium phosphatebone regenerationbone substitutescone–beam computed tomographyosteoconductiontooth extraction

Identifiers

PMID42188414
PMCPMC13207125

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.