ArticleAlcohol, clinical & experimental research2026
Prenatal Alcohol Exposure and the Development of Multiple Risk Behaviors in Adolescence: A Birth Cohort Study.
Article in Alcohol, clinical & experimental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundThe United Kingdom has the fourth highest estimated prevalence globally of maternal alcohol consumption during pregnancy (41%). It is therefore important to understand the long-term impacts of prenatal alcohol exposure (PAE) by examining its impact on the development of adolescent multiple risk behaviors (MRBs) that may increase morbidity and premature mortality across the life-course.
methodsUsing Avon Longitudinal Study of Parents and Children (ALSPAC) cohort data with multiple imputation (n = 6752), we examined the impacts of "infrequent," "frequent," and "binge" PAE groups on the development of seven MRBs at 16 years old, encompassing substance misuse, risky sexual behavior, and antisocial behavior. Data were analyzed using multiple regression, using q-statistics to adjust for multiple comparisons.
resultsAdolescents with "infrequent" and "frequent" PAE were more likely to develop hazardous alcohol use at 16 years old compared to those without PAE, with the strongest association being for the "frequent" group (adjusted odds ratio [aOR] 1.45 [1.19-1.76], p < 0.001, q value = 0.005). Adolescents exposed to binge drinking prenatally had an increased risk of engaging in underage sexual intercourse (aOR 1.34 [1.09-1.64], p = 0.005, q value = 0.044). Binge drinking predicted a higher total MRB score (Coefficient = +0.21 [+0.08 to +0.33], p = 0.001, q value = 0.017).
conclusionsThis study supports the UK Chief Medical Officer's Low Risk Drinking Guidelines that the safest approach if pregnant, or if there is a possibility of becoming pregnant, is to avoid drinking alcohol, with the more alcohol consumed during pregnancy the greater the risks of long-term harm to the baby. Given the findings that PAE may increase the risk of adolescent hazardous alcohol use and risky sexual behavior, this study highlights the need for further research to understand the intergenerational effects of PAE.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.