ArticleActa diabetologica2026
Long-term imaging characteristics of the pancreas related to diabetes induced by immune checkpoint inhibitor therapy.
Article in Acta diabetologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundImmune checkpoint inhibitor (ICI)-induced diabetes is a rare endocrine immune-related adverse event, and long-term pancreatic magnetic resonance imaging (MRI) findings after disease onset have not been well characterized. CASE PRESENTATION: An individual developed abrupt hyperglycemia during pembrolizumab therapy for recurrent renal cell carcinoma and subsequently required insulin therapy. Serum C-peptide rapidly declined to below the detection threshold, whereas pancreatic enzyme levels remained within normal limits throughout follow-up. MRI performed 1 day after diagnosis demonstrated diffuse high signal intensity on diffusion-weighted imaging (DWI) and reduced apparent diffusion coefficient (ADC) values throughout the pancreas. Serial imaging over 25 months showed progressive pancreatic atrophy, whereas the DWI/ADC features persisted.
conclusionThis case provides a new descriptive longitudinal radiological observation of persistent diffusion-related pancreatic MRI findings and progressive pancreatic atrophy after the onset of ICI-induced diabetes.
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