Evidence map›Paper›PMID 42189234›Full record

ArticleThe Journal of membrane biology2026

Evolutionary Prevalence of the Electrostatic Switch Mechanism in P-type ATPases.

Nikita S Badve, Alyssa V Buda, Jonas A Káral, Zhitong Li, Taylah L Percival, Sofia Y Wardman, Sophia G Tran, Simon Y W Ho, Ronald J Clarke

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of membrane biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nikita S BadveSchool of Chemistry, University of Sydney, Sydney, NSW, 2006, Australia.
Alyssa V BudaSchool of Chemistry, University of Sydney, Sydney, NSW, 2006, Australia.
Jonas A KáralSchool of Chemistry, University of Sydney, Sydney, NSW, 2006, Australia.
Zhitong LiSchool of Chemistry, University of Sydney, Sydney, NSW, 2006, Australia.
Taylah L PercivalSchool of Chemistry, University of Sydney, Sydney, NSW, 2006, Australia.
Sofia Y WardmanSchool of Chemistry, University of Sydney, Sydney, NSW, 2006, Australia.
Sophia G TranSchool of Chemistry, University of Sydney, Sydney, NSW, 2006, Australia.
Simon Y W HoSchool of Life and Environmental Sciences, University of Sydney, Sydney, NSW, 2006, Australia.ORCID http://orcid.org/0000-0002-0361-2307
Ronald J ClarkeSchool of Chemistry, University of Sydney, Sydney, NSW, 2006, Australia. ronald.clarke@sydney.edu.au.ORCID http://orcid.org/0000-0002-0950-8017

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

P-type ATPases are active transporter enzymes that maintain ion electrochemical gradients for functions such as muscle contraction, kidney function, digestion, and nerve signalling. The dysfunction of these ATPases has been linked to several neurological, cardiovascular, and metabolic disorders. An electrostatic switch mechanism (ESM) has been hypothesised to be involved in the regulation of the sodium-potassium pump (Na

Indexed as

Evolution, MolecularP-type ATPasesStatic ElectricityAnimalsHumansModels, MolecularPhylogenyP-type ATPasesFlippaseLipidMembrane proteinProton pumpRegulationSodium pump

Identifiers

PMID42189234
PMCPMC13212812

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.