Evidence map›Paper›PMID 42189296›Full record

ArticleMolecular biology reports2026

Phosphorylation of AEG-1 suppresses NF-κB signaling in gastric cancer.

Qihao Sun, Zhihui Bai, Jiajie Sun, Tiantian Xiao, Qingqing Zhang, Xinyuxue Yang, Xuerong Wang, Zuhao Zhang, Wenbin Huang

Abstract read
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In one paragraph

Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qihao SunDepartment of Pharmacology, School of Basic Medical Sciences, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, Jiangsu Province, China.
Zhihui BaiDepartment of Pharmacology, School of Basic Medical Sciences, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, Jiangsu Province, China.
Jiajie SunDepartment of Pharmacology, School of Basic Medical Sciences, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, Jiangsu Province, China.
Tiantian XiaoDepartment of Pathology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, 24 Jinghua Road, Luoyang, 471003, Henan Province, China.
Qingqing ZhangDepartment of Pathology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, 24 Jinghua Road, Luoyang, 471003, Henan Province, China.
Xinyuxue YangDepartment of Pharmacology, School of Basic Medical Sciences, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, Jiangsu Province, China.
Xuerong WangDepartment of Pharmacology, School of Basic Medical Sciences, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, Jiangsu Province, China. wangxr@njmu.edu.cn.ORCID http://orcid.org/0000-0002-3040-9435
Zuhao ZhangDepartment of Pharmacology, School of Basic Medical Sciences, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, Jiangsu Province, China. aiyou0620@163.com.
Wenbin HuangDepartment of Pathology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, 24 Jinghua Road, Luoyang, 471003, Henan Province, China. wbhuang348912@126.com.ORCID http://orcid.org/0000-0002-6544-1144

Funding

2024 Shining Across China - Pharmaceutical Research Capacity Building Fund Z04j2023E095a Joint Grant of Science and Technology Investigation of Henan Province 242103810042a key project of the Science and Technology Development of Luoyang 2302015Athe National Natural Science Foundation of China 81972763
6 · The paper itself

Abstract

Astrocyte elevated gene-1 (AEG-1) is oncogenic in gastric cancer; however, its underlying mechanism has not been fully elucidated. In this study, we identified serine 308 (Ser308) as a phosphorylation site of AEG-1 in gastric cancer cells. By constructing AEG-1 point mutants to overexpress phospho-mimetic AEG-1 (S308D, serine-to-aspartate) and dephospho-mimetic AEG-1 (S308A, serine-to-alanine), we found that phosphorylation of AEG-1 at Ser308 significantly suppressed cell growth and migration, accompanied by downregulation of p65 NF-κB-mediated transcription of the downstream target genes FOS and IL-8. Mechanistically, TNF-α-induced dephosphorylation of AEG-1 at Ser308 promoted p65 NF-κB nuclear accumulation and activation through protein-protein interaction. This study reveals a novel phosphorylation-dependent switch that regulates AEG-1-mediated NF-κB signaling in gastric cancer.

Indexed as

Cell Adhesion MoleculesNF-kappa BStomach NeoplasmsCell Line, TumorCell MovementCell ProliferationGene Expression Regulation, NeoplasticHumansInterleukin-8Membrane ProteinsPhosphorylationRNA-Binding ProteinsSignal TransductionTranscription Factor RelATumor Necrosis Factor-alphaCell Adhesion MoleculesInterleukin-8Membrane ProteinsMTDH protein, humanNF-kappa BRNA-Binding ProteinsTranscription Factor RelATumor Necrosis Factor-alphaAEG-1Gastric cancerNF-κBPhosphorylation

Identifiers

PMID42189296

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.