Evidence map›Paper›PMID 42189395›Full record

ArticleMedScience2026

Identification of end-stage renal disease-associated loci in X chromosome: an X chromosome-wide association study.

Xiaohong Zhou, Dianchun Shi, Ming Li, Yibin Liu, Zhiming Ye, Wei Chen, Meng Wang, Dongying Fu, Yanna Wang, Hua Gan and 7 more

Abstract read
PubMed Publisher
In one paragraph

Article in MedScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Xiaohong Zhou *School of Medicine, South China University of Technology, Guangzhou, 510640, China.
Dianchun Shi *Department of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, China.
Ming LiDepartment of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, China.
Yibin LiuSchool of Medicine, South China University of Technology, Guangzhou, 510640, China.
Zhiming YeDepartment of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, China.
Wei ChenDepartment of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
Meng WangDepartment of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
Dongying FuDepartment of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
Yanna WangDepartment of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, China.
Hua GanDepartment of Nephrology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Ping FuDivision of Nephrology and National Clinical Research Center for Geriatrics, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, 610041, China.
Xiaojun TanDepartment of Nephrology, Kaiping Central Hospital, Jiangmen, 529300, China.
Yaozhong KongDivision of Nephrology, The First People's Hospital of Foshan, Foshan, 528000, China.
Jihong ChenDepartment of Nephrology, Affiliated Bao'an Hospital of Shenzhen, The Second School of Clinical Medicine, Southern Medical University, Shenzhen, 518101, China.
Jinghong ZhaoDepartment of Nephrology, The Key Laboratory for The Prevention and Treatment of Chronic Kidney Disease of Chongqing, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, China.
Xueqing YuDepartment of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, China. yuxueqing@gdph.org.cn.
Jianjun LiuSchool of Medicine, South China University of Technology, Guangzhou, 510640, China. liuj3@gis.a-star.edu.sg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

X-chromosomal genetic variants have been understudied in end-stage renal disease (ESRD), which holds the promise to provide valuable insights into sexually dimorphic traits and diseases. Here we performed an X chromosome-wide association study (XWAS) in a Chinese cohort (N = 2750), comprising 1489 cases with ESRD and 1261 controls, to identify locus associated with ESRD risk. One locus showing a consistent effect direction across sex but primarily supported by the male cohort was identified in COL4A5 (P = 2.43 × 10

Indexed as

Chromosomes, Human, XKidney Failure, ChronicCollagen Type IVFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMicroRNAsPolymorphism, Single NucleotideCOL4A5 protein, humanCollagen Type IVMicroRNAsend-stage renal diseasegenotypesexually dimorphic traitssingle nucleotide polymorphismX chromosome-wide association study

Identifiers

PMID42189395

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.