Evidence mapPaperPMID 42189397Full record

ReviewWorld journal of microbiology & biotechnology2026

Microbial production of xanthohumol driven by synthetic biology approaches.

Yidan Hu, Yiwen Yu, Jung-Kul Lee, Vipin Chandra Kalia, Hongtao Bi, Chunjie Gong

Abstract readReview
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In one paragraph

Review in World journal of microbiology & biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yidan HuKey Laboratory of Fermentation Engineering (Ministry of Education), Cooperative Innovation enter of Industrial Fermentation (Ministry of Education & Hubei Province), National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan, 430068, PR China.
Yiwen YuKey Laboratory of Fermentation Engineering (Ministry of Education), Cooperative Innovation enter of Industrial Fermentation (Ministry of Education & Hubei Province), National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan, 430068, PR China.
Jung-Kul LeeDepartment of Chemical Engineering, Konkuk University, 1 Hwayang-Dong, Gwangjin-Gu, Seoul, 05029, Republic of Korea.
Vipin Chandra KaliaDepartment of Chemical Engineering, Konkuk University, 1 Hwayang-Dong, Gwangjin-Gu, Seoul, 05029, Republic of Korea.
Hongtao BiQinghai Provincial Key Laboratory of Tibetan Medicine Pharmacology and Safety Evaluation, Northwest Institute of Plateau Biology, Chinese Academy of Science, Xining, 810008, China.
Chunjie GongKey Laboratory of Fermentation Engineering (Ministry of Education), Cooperative Innovation enter of Industrial Fermentation (Ministry of Education & Hubei Province), National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan, 430068, PR China. gongcj606@163.com.

Funding

National Natural Science Foundation of China 32570149
6 · The paper itself

Abstract

Xanthohumol is a high-value natural product with unique features, such as its antioxidant, anti-inflammatory, and anticancer properties. The excellent features enable its wide utilization in the cosmetic, pharmaceutical, nutraceutical, and food industries. However, the low yields and high production costs impede its large-scale production significantly. Its sustainable production has been limited by inefficient, costly, and environmentally unfriendly conventional extraction processes. Recently, the development of microbial synthetic biology has provided a reliable, scalable, and eco-friendly mechanism for xanthohumol production. In this paper, the development of bio-strategies for the commercial-scale production of xanthohumol is summarized. Furthermore, the techno-economic feasibility was also evaluated. In the future, further attempt will still be required for xanthohumol production using synthetic biology.

Indexed as

BacteriaFlavonoidsPropiophenonesSynthetic BiologyAntioxidantsBiological ProductsIndustrial MicrobiologyAntioxidantsBiological ProductsFlavonoidsPropiophenonesxanthohumolMicrobial productionSynthetic biologyTechno-economic feasibilityXanthohumol

Identifiers

PMID42189397

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.