Evidence map›Paper›PMID 42189484›Full record

ArticleJournal of endocrinological investigation2026

fNIRS estimates prefrontal cortex activation following glucose load in youths with obesity.

Gabriele Scozia, Deny Menghini, Stefano Lasaponara, Alessia Aureli, Chiara Carducci, Valentina Quaresima, Roberto Isabella, Fabrizio Doricchi, Stefano Vicari, Stefano Cianfarani and 2 more

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In one paragraph

Article in Journal of endocrinological investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Gabriele ScoziaChild and Adolescent Neuropsychiatry Unit, Department of Neurological and Psychiatric Science, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.ORCID http://orcid.org/0000-0002-8388-2568
Deny MenghiniChild and Adolescent Neuropsychiatry Unit, Department of Neurological and Psychiatric Science, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.ORCID http://orcid.org/0000-0002-3459-2601
Stefano LasaponaraDipartimento di Psicologia, Università degli Studi di Roma 'La Sapienza', Rome, Italy.ORCID http://orcid.org/0000-0001-5325-2621
Alessia AureliEndocrinology and Diabetes Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.ORCID http://orcid.org/0000-0001-9216-8609
Chiara CarducciChild and Adolescent Neuropsychiatry Unit, Department of Neurological and Psychiatric Science, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.ORCID http://orcid.org/0000-0002-0809-5716
Valentina QuaresimaDipartimento di Medicina Clinica, Sanità Pubblica, Scienze della Vita e dell'Ambiente, Università degli Studi dell'Aquila, L'Aquila, Italy.ORCID http://orcid.org/0000-0001-9884-0304
Roberto IsabellaKeyRIB for ANUA E.T.S. Association - Social Enterprise, Rome, Italy.ORCID http://orcid.org/0000-0003-0812-0990
Fabrizio DoricchiDipartimento di Psicologia, Università degli Studi di Roma 'La Sapienza', Rome, Italy.ORCID http://orcid.org/0000-0002-1535-9046
Stefano VicariChild and Adolescent Neuropsychiatry Unit, Department of Neurological and Psychiatric Science, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.ORCID http://orcid.org/0000-0002-5395-2262
Stefano CianfaraniEndocrinology and Diabetes Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.ORCID http://orcid.org/0000-0002-2580-8781
Danilo FintiniEndocrinology and Diabetes Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.ORCID http://orcid.org/0000-0001-5826-0276
Melania MancoUnit of Preventive and Predictive Medicine, Bambino Gesù Children's Hospital, IRCCS, Via F. Baldelli 38, 00146, Rome, Italy. melania.manco@opbg.net.ORCID http://orcid.org/0000-0002-6581-975X

Funding

Ministero della Salute Italian Ministry of HealthMinistero della Salute PNRR Call for Proposals (PNRR-MAD-2022-12376459 to Melania Manco "funded by the European Union -Next Generation EU -NRRP M6C2 -Investement 2.1 EnancementMinistero della Salute Strenghtening of Biomedical Research in the NHS"). This work was also founded by the Italian Ministry of Health with current research founds.
6 · The paper itself

Abstract

purposeThe prefrontal cortex [PFC] is crucial in controlling food-related impulses. Functional near-infrared spectroscopy [fNIRS] represents a wearable functional neuroimaging technology for measuring PFC activation in real life. Aims of the study were to examine PFC activation in fasting conditions and after an oral glucose tolerance test [OGTT] in resting- state [R], cognitive tasks [Ts] conditions and explore the PFC activation relationship with insulin sensitivity index [ISI] in youths with obesity.

methods28 patients' cross-sectional study [age 7-15 y]. ISI was quantified by Matsuda's Index and PFC activation as oxygenated [O

resultsDorsolateral PFC [DLPFC] and right frontal pole were over-activated in OGTT compared to the fasting state. Significant differences [p < 0.005, false discovery rate corrected] were observed: P2 [O

conclusionfNIRS enabled the non-invasive examination of the PFC hemodynamic response associated with participants' insulin sensitivity in an ecological context. Bilateral DLPFC activation following OGTT in youths with obesity was associated with peripheral ISI. This association suggests that peripheral insulin sensitivity might reflect the PFC's ability to control food-related behaviours.

Indexed as

ChildrenDorsolateral prefrontal cortexFunctional near-infrared spectroscopyInsulin sensitivityObesity

Identifiers

PMID42189484

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.