SynthesisHaemophilia : the official journal of the World Federation of Hemophilia
Perioperative Outcomes in Factor XI Deficiency: A Systematic Review.
Synthesis in Haemophilia : the official journal of the World Federation of Hemophilia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCongenital factor XI (FXI) deficiency has a variable bleeding phenotype, and FXI activity alone does not predict perioperative bleeding. Management practices remain heterogeneous, and available evidence derives from case reports, small case series, and retrospective cohorts. This systematic review evaluated perioperative bleeding outcomes and management strategies in FXI-deficient patients undergoing surgical procedures.
methodsWe systematically searched five databases (2016-2024). Two reviewers independently screened studies, extracted data, and assessed methodological quality. Because of heterogeneity among studies, cohort data were synthesized qualitatively. Case reports were summarized descriptively, and an exploratory framework combining FXI category and fibrinolytic risk of the procedure was constructed to illustrate patterns in bleeding outcomes.
resultsTwenty-one studies met inclusion criteria: four retrospective cohorts and seventeen case reports, describing more than 590 procedures. Cohort bleeding rates ranged from 0% to 19%, with major bleeding ≤ 7%. FXI activity showed no consistent association with perioperative bleeding. Procedural factors and personal bleeding history are more often aligned with outcomes. Most case reports involved severe FXI deficiency and used FFP-based prophylaxis, often with antifibrinolytics. Bleeding events in case reports were infrequent. In the exploratory two-dimensional visualization, bleeding appeared more common among patients with FXI ≤ 10 IU/dL undergoing high-fibrinolytic procedures; however, event numbers were small and prophylaxis was widely used, limiting interpretation.
conclusionsFXI levels alone appear insufficient to predict bleeding risk in FXI-deficient patients. A multifactorial approach, integrating surgical risk and haemostatic strategy, may be required, and further study is needed to optimize preoperative management strategies for FXI-deficient patients. CLINICAL
trial registrationClinical trial registration was not applicable for this study.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.